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Akt-Signal Integration Is Involved in the Differentiation of Embryonal Carcinoma Cells

The mechanism by which Akt modulates stem cell homeostasis is still incompletely defined. Here we demonstrate that Akt phosphorylates special AT-rich sequences binding protein 1 (SATB1) at serine 47 and protects SATB1 from apoptotic cleavage. Meanwhile, Akt phosphorylates Oct4 at threonine 228 and K...

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Detalles Bibliográficos
Autores principales:	Chen, Bo, Xue, Zheng, Yang, Guanghui, Shi, Bingyang, Yang, Ben, Yan, Yuemin, Wang, Xue, Han, Daishu, Huang, Yue, Dong, Wenji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675137/ https://www.ncbi.nlm.nih.gov/pubmed/23762260 http://dx.doi.org/10.1371/journal.pone.0064877

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