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COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers

The COMT Val158Met polymorphism may be a risk factor for nicotine addiction. This study examined the influence of the COMT Val158Met polymorphism on subjective, physiological, and cognitive effects of intravenous (IV) nicotine use in African American (AAs) (n=56) and European American (EAs) (n=68) s...

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Autores principales: Herman, Aryeh I., Jatlow, Peter I., Gelernter, Joel, Listman, Jennifer B., Sofuoglu, Mehmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675163/
https://www.ncbi.nlm.nih.gov/pubmed/23459442
http://dx.doi.org/10.1038/tpj.2013.1
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author Herman, Aryeh I.
Jatlow, Peter I.
Gelernter, Joel
Listman, Jennifer B.
Sofuoglu, Mehmet
author_facet Herman, Aryeh I.
Jatlow, Peter I.
Gelernter, Joel
Listman, Jennifer B.
Sofuoglu, Mehmet
author_sort Herman, Aryeh I.
collection PubMed
description The COMT Val158Met polymorphism may be a risk factor for nicotine addiction. This study examined the influence of the COMT Val158Met polymorphism on subjective, physiological, and cognitive effects of intravenous (IV) nicotine use in African American (AAs) (n=56) and European American (EAs) (n=68) smokers. Overnight abstinent smokers received saline followed by 0.5 and 1.0 mg/70 kg doses of nicotine, administered 30 minutes apart. Smokers with Val/Val genotype, compared to Met carriers, had greater negative subjective effects from IV nicotine and had more severe withdrawal severity following overnight abstinence from smoking. Women with Val/Val genotype reported greater difficulty concentrating and irritability than men with Val/Val or Met carrier genotypes. The Val/Val genotype was associated with better performance on the math task and in AA smokers it was associated with greater systolic blood pressure. These results support the rationale of pharmacologically inhibiting COMT to aid with smoking cessation among Val/Val genotype smokers.
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spelling pubmed-36751632014-06-01 COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers Herman, Aryeh I. Jatlow, Peter I. Gelernter, Joel Listman, Jennifer B. Sofuoglu, Mehmet Pharmacogenomics J Article The COMT Val158Met polymorphism may be a risk factor for nicotine addiction. This study examined the influence of the COMT Val158Met polymorphism on subjective, physiological, and cognitive effects of intravenous (IV) nicotine use in African American (AAs) (n=56) and European American (EAs) (n=68) smokers. Overnight abstinent smokers received saline followed by 0.5 and 1.0 mg/70 kg doses of nicotine, administered 30 minutes apart. Smokers with Val/Val genotype, compared to Met carriers, had greater negative subjective effects from IV nicotine and had more severe withdrawal severity following overnight abstinence from smoking. Women with Val/Val genotype reported greater difficulty concentrating and irritability than men with Val/Val or Met carrier genotypes. The Val/Val genotype was associated with better performance on the math task and in AA smokers it was associated with greater systolic blood pressure. These results support the rationale of pharmacologically inhibiting COMT to aid with smoking cessation among Val/Val genotype smokers. 2013-03-05 2013-12 /pmc/articles/PMC3675163/ /pubmed/23459442 http://dx.doi.org/10.1038/tpj.2013.1 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Herman, Aryeh I.
Jatlow, Peter I.
Gelernter, Joel
Listman, Jennifer B.
Sofuoglu, Mehmet
COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers
title COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers
title_full COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers
title_fullStr COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers
title_full_unstemmed COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers
title_short COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers
title_sort comt val158met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675163/
https://www.ncbi.nlm.nih.gov/pubmed/23459442
http://dx.doi.org/10.1038/tpj.2013.1
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