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Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial
OBJECTIVE: Depression is associated with increased risk for obesity and worse weight loss treatment outcomes. The purpose of the present study was to test the hypothesis that delivering evidence-based behavior therapy for depression prior to a lifestyle weight loss intervention improves both weight...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675166/ https://www.ncbi.nlm.nih.gov/pubmed/23459323 http://dx.doi.org/10.1038/ijo.2013.25 |
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author | Pagoto, Sherry Schneider, Kristin L. Whited, Matthew C. Oleski, Jessica L. Merriam, Phillip Appelhans, Bradley Ma, Yunsheng Olendzki, Barbara Waring, Molly E. Busch, Andrew M. Lemon, Stephenie Ockene, Ira Crawford, Sybil |
author_facet | Pagoto, Sherry Schneider, Kristin L. Whited, Matthew C. Oleski, Jessica L. Merriam, Phillip Appelhans, Bradley Ma, Yunsheng Olendzki, Barbara Waring, Molly E. Busch, Andrew M. Lemon, Stephenie Ockene, Ira Crawford, Sybil |
author_sort | Pagoto, Sherry |
collection | PubMed |
description | OBJECTIVE: Depression is associated with increased risk for obesity and worse weight loss treatment outcomes. The purpose of the present study was to test the hypothesis that delivering evidence-based behavior therapy for depression prior to a lifestyle weight loss intervention improves both weight loss and depression. DESIGN: In a randomized controlled trial, obese women with major depressive disorder (N=161, mean age=45.9 [SD: 10.8] years) were randomized to brief behavior therapy for depression treatment followed by a lifestyle intervention (BA) or a lifestyle intervention only (LI). Follow-up occurred at 6- and 12-months. Main outcome measures included weight loss and depression symptoms. RESULTS: Intention-to-treat analyses revealed both conditions lost significant weight, but no differences between conditions in weight change at 6-months (BA= −3.0%, SE= − 0.65%; LI=−3.7%, SE = 0.63%; p = 0.48) or 12-months (BA= −2.6%, SE= 0.77%; LI= −3.1%, SE=0.74%; p= 0.72). However, the BA condition evidenced significantly greater improvement in Beck Depression Inventory-II scores relative to the LI condition at both 6-months (BA mean change= −12.5, SD= 0.85; LI mean change= −9.2, SD=0.80, p= 0.005) and 12-months (BA mean change= −-12.6, SD= 0.97; LI mean change= −9.9, SD= 0.93; p = 0.045). Participants who experienced depression remission by 6-months (61.2%) lost greater weight (mean = −4.31%; SE=0.052) than those who did not (39.7%; mean= −2.47%, SE=0.53; p=.001). CONCLUSION: Adding behavior therapy to a lifestyle intervention results in greater depression remission but does not improve weight loss within one year. Improvement in depression is associated with greater weight loss. |
format | Online Article Text |
id | pubmed-3675166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
record_format | MEDLINE/PubMed |
spelling | pubmed-36751662014-05-01 Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial Pagoto, Sherry Schneider, Kristin L. Whited, Matthew C. Oleski, Jessica L. Merriam, Phillip Appelhans, Bradley Ma, Yunsheng Olendzki, Barbara Waring, Molly E. Busch, Andrew M. Lemon, Stephenie Ockene, Ira Crawford, Sybil Int J Obes (Lond) Article OBJECTIVE: Depression is associated with increased risk for obesity and worse weight loss treatment outcomes. The purpose of the present study was to test the hypothesis that delivering evidence-based behavior therapy for depression prior to a lifestyle weight loss intervention improves both weight loss and depression. DESIGN: In a randomized controlled trial, obese women with major depressive disorder (N=161, mean age=45.9 [SD: 10.8] years) were randomized to brief behavior therapy for depression treatment followed by a lifestyle intervention (BA) or a lifestyle intervention only (LI). Follow-up occurred at 6- and 12-months. Main outcome measures included weight loss and depression symptoms. RESULTS: Intention-to-treat analyses revealed both conditions lost significant weight, but no differences between conditions in weight change at 6-months (BA= −3.0%, SE= − 0.65%; LI=−3.7%, SE = 0.63%; p = 0.48) or 12-months (BA= −2.6%, SE= 0.77%; LI= −3.1%, SE=0.74%; p= 0.72). However, the BA condition evidenced significantly greater improvement in Beck Depression Inventory-II scores relative to the LI condition at both 6-months (BA mean change= −12.5, SD= 0.85; LI mean change= −9.2, SD=0.80, p= 0.005) and 12-months (BA mean change= −-12.6, SD= 0.97; LI mean change= −9.9, SD= 0.93; p = 0.045). Participants who experienced depression remission by 6-months (61.2%) lost greater weight (mean = −4.31%; SE=0.052) than those who did not (39.7%; mean= −2.47%, SE=0.53; p=.001). CONCLUSION: Adding behavior therapy to a lifestyle intervention results in greater depression remission but does not improve weight loss within one year. Improvement in depression is associated with greater weight loss. 2013-03-05 2013-11 /pmc/articles/PMC3675166/ /pubmed/23459323 http://dx.doi.org/10.1038/ijo.2013.25 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Pagoto, Sherry Schneider, Kristin L. Whited, Matthew C. Oleski, Jessica L. Merriam, Phillip Appelhans, Bradley Ma, Yunsheng Olendzki, Barbara Waring, Molly E. Busch, Andrew M. Lemon, Stephenie Ockene, Ira Crawford, Sybil Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial |
title | Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial |
title_full | Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial |
title_fullStr | Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial |
title_full_unstemmed | Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial |
title_short | Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial |
title_sort | randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the be active trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675166/ https://www.ncbi.nlm.nih.gov/pubmed/23459323 http://dx.doi.org/10.1038/ijo.2013.25 |
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