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A Role for Uric Acid and the Nalp3 Inflammasome in Antiphospholipid Antibody-Induced IL-1β Production by Human First Trimester Trophoblast

Women with antiphospholipid syndrome (APS) are at risk of recurrent pregnancy loss and obstetrical disorders, such as preeclampsia and intrauterine growth restriction (IUGR). Antiphospholipid antibodies (aPL) directly target the placenta by binding beta(2)-glycoprotein I (β(2)GPI) expressed on the t...

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Detalles Bibliográficos
Autores principales: Mulla, Melissa J., Salmon, Jane E., Chamley, Larry W., Brosens, Jan J., Boeras, Crina M., Kavathas, Paula B., Abrahams, Vikki M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675211/
https://www.ncbi.nlm.nih.gov/pubmed/23762324
http://dx.doi.org/10.1371/journal.pone.0065237