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Iron metabolism and risk of cancer in the Swedish AMORIS study

OBJECTIVES: Pre-clinical studies have shown that iron can be carcinogenic, but few population-based studies investigated the association between markers of the iron metabolism and risk of cancer while taking into account inflammation. We assessed the link between serum iron (SI), total-iron binding...

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Autores principales: Gaur, Anjali, Collins, Helen, Wulaningsih, Wahyu, Holmberg, Lars, Garmo, Hans, Hammar, Niklas, Walldius, Göran, Jungner, Ingmar, Van Hemelrijck, Mieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675271/
https://www.ncbi.nlm.nih.gov/pubmed/23649231
http://dx.doi.org/10.1007/s10552-013-0219-8
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author Gaur, Anjali
Collins, Helen
Wulaningsih, Wahyu
Holmberg, Lars
Garmo, Hans
Hammar, Niklas
Walldius, Göran
Jungner, Ingmar
Van Hemelrijck, Mieke
author_facet Gaur, Anjali
Collins, Helen
Wulaningsih, Wahyu
Holmberg, Lars
Garmo, Hans
Hammar, Niklas
Walldius, Göran
Jungner, Ingmar
Van Hemelrijck, Mieke
author_sort Gaur, Anjali
collection PubMed
description OBJECTIVES: Pre-clinical studies have shown that iron can be carcinogenic, but few population-based studies investigated the association between markers of the iron metabolism and risk of cancer while taking into account inflammation. We assessed the link between serum iron (SI), total-iron binding capacity (TIBC), and risk of cancer by levels of C-reactive protein (CRP) in a large population-based study (n = 220,642). METHODS: From the Swedish Apolipoprotein Mortality Risk (AMORIS) study, we selected all participants (>20 years old) with baseline measurements of serum SI, TIBC, and CRP. Multivariate Cox proportional hazards regression was carried out for standardized and quartile values of SI and TIBC. Similar analyses were performed for specific cancers (pancreatic, colon, liver, respiratory, kidney, prostate, stomach, and breast cancer). To avoid reverse causation, we excluded those with follow-up <3 years. RESULTS: We found a positive association between standardized TIBC and overall cancer [HR 1.03 (95 % CI 1.01–1.05)]. No statistically significant association was found between SI and cancer risk except for postmenopausal breast cancer [HR for standardized SI 1.09 (95 % CI 1.02–1.15)]. The association between TIBC and specific cancer was only statistically significant for colon cancer [i.e., HR for standardized TIBC: 1.17 (95 % CI 1.08–1.28)]. A borderline interaction between SI and levels of CRP was observed only in stomach cancer. CONCLUSIONS: As opposed to pre-clinical findings for serum iron and cancer, this population-based epidemiological study showed an inverse relation between iron metabolism and cancer risk. Minimal role of inflammatory markers observed warrants further study focusing on developments of specific cancers.
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spelling pubmed-36752712013-06-10 Iron metabolism and risk of cancer in the Swedish AMORIS study Gaur, Anjali Collins, Helen Wulaningsih, Wahyu Holmberg, Lars Garmo, Hans Hammar, Niklas Walldius, Göran Jungner, Ingmar Van Hemelrijck, Mieke Cancer Causes Control Original Paper OBJECTIVES: Pre-clinical studies have shown that iron can be carcinogenic, but few population-based studies investigated the association between markers of the iron metabolism and risk of cancer while taking into account inflammation. We assessed the link between serum iron (SI), total-iron binding capacity (TIBC), and risk of cancer by levels of C-reactive protein (CRP) in a large population-based study (n = 220,642). METHODS: From the Swedish Apolipoprotein Mortality Risk (AMORIS) study, we selected all participants (>20 years old) with baseline measurements of serum SI, TIBC, and CRP. Multivariate Cox proportional hazards regression was carried out for standardized and quartile values of SI and TIBC. Similar analyses were performed for specific cancers (pancreatic, colon, liver, respiratory, kidney, prostate, stomach, and breast cancer). To avoid reverse causation, we excluded those with follow-up <3 years. RESULTS: We found a positive association between standardized TIBC and overall cancer [HR 1.03 (95 % CI 1.01–1.05)]. No statistically significant association was found between SI and cancer risk except for postmenopausal breast cancer [HR for standardized SI 1.09 (95 % CI 1.02–1.15)]. The association between TIBC and specific cancer was only statistically significant for colon cancer [i.e., HR for standardized TIBC: 1.17 (95 % CI 1.08–1.28)]. A borderline interaction between SI and levels of CRP was observed only in stomach cancer. CONCLUSIONS: As opposed to pre-clinical findings for serum iron and cancer, this population-based epidemiological study showed an inverse relation between iron metabolism and cancer risk. Minimal role of inflammatory markers observed warrants further study focusing on developments of specific cancers. Springer Netherlands 2013-05-07 2013 /pmc/articles/PMC3675271/ /pubmed/23649231 http://dx.doi.org/10.1007/s10552-013-0219-8 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Paper
Gaur, Anjali
Collins, Helen
Wulaningsih, Wahyu
Holmberg, Lars
Garmo, Hans
Hammar, Niklas
Walldius, Göran
Jungner, Ingmar
Van Hemelrijck, Mieke
Iron metabolism and risk of cancer in the Swedish AMORIS study
title Iron metabolism and risk of cancer in the Swedish AMORIS study
title_full Iron metabolism and risk of cancer in the Swedish AMORIS study
title_fullStr Iron metabolism and risk of cancer in the Swedish AMORIS study
title_full_unstemmed Iron metabolism and risk of cancer in the Swedish AMORIS study
title_short Iron metabolism and risk of cancer in the Swedish AMORIS study
title_sort iron metabolism and risk of cancer in the swedish amoris study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675271/
https://www.ncbi.nlm.nih.gov/pubmed/23649231
http://dx.doi.org/10.1007/s10552-013-0219-8
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