Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis

Geminin, an essential factor for DNA replication, directly binds to the licensing factor Cdt1 and inhibits pre-replicative complex formation to prevent re-replication. In G1, geminin levels are controlled by the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase complex, which targets gem...

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Detalles Bibliográficos
Autores principales: Tsunematsu, Takaaki, Takihara, Yoshihiro, Ishimaru, Naozumi, Pagano, Michele, Takata, Takashi, Kudo, Yasusei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675325/
https://www.ncbi.nlm.nih.gov/pubmed/23695679
http://dx.doi.org/10.1038/ncomms2859

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