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Crystal structures of Escherichia coli exonuclease I in complex with single-stranded DNA provide insights into the mechanism of processive digestion

Escherichia coli Exonuclease I (ExoI) digests single-stranded DNA (ssDNA) in the 3′-5′ direction in a highly processive manner. The crystal structure of ExoI, determined previously in the absence of DNA, revealed a C-shaped molecule with three domains that form a central positively charged groove. T...

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Detalles Bibliográficos
Autores principales:	Korada, Sai Krishna C., Johns, Trevor D., Smith, Christopher E., Jones, Nathan D., McCabe, Kimberly A., Bell, Charles E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675492/ https://www.ncbi.nlm.nih.gov/pubmed/23609540 http://dx.doi.org/10.1093/nar/gkt278

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