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Thyroid-Stimulating Hormone Is Significantly Associated with Bone Health Status in Men

Background and Aim: Recent studies revealed a novel association between thyroid-stimulating hormone (TSH) and bone health status in healthy male populations. The present study aimed to validate this association and provide new information on the relationship between TSH levels and calcaneal speed of...

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Autores principales: Chin, Kok-Yong, Ima-Nirwana, Soelaiman, Mohamed, Isa Naina, Aminuddin, Amilia, Johari, Mohamad Hanapi, Ngah, Wan Zurinah Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675499/
https://www.ncbi.nlm.nih.gov/pubmed/23781131
http://dx.doi.org/10.7150/ijms.5870
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author Chin, Kok-Yong
Ima-Nirwana, Soelaiman
Mohamed, Isa Naina
Aminuddin, Amilia
Johari, Mohamad Hanapi
Ngah, Wan Zurinah Wan
author_facet Chin, Kok-Yong
Ima-Nirwana, Soelaiman
Mohamed, Isa Naina
Aminuddin, Amilia
Johari, Mohamad Hanapi
Ngah, Wan Zurinah Wan
author_sort Chin, Kok-Yong
collection PubMed
description Background and Aim: Recent studies revealed a novel association between thyroid-stimulating hormone (TSH) and bone health status in healthy male populations. The present study aimed to validate this association and provide new information on the relationship between TSH levels and calcaneal speed of sound (SOS) in men. Methods: This cross-sectional study recruited 681 men with complete data of calcaneal SOS, body anthropometry, serum TSH, free triiodothyronine (FT3) and free thyroxine (FT4) levels. Results: All subjects had FT3 and FT4 levels within the in-house reference range and 13 subjects had lower than normal TSH levels. The results revealed that the SOS value of subjects was significantly associated with TSH after multiple adjustments (p<0.05). When subjects were divided into quintiles according to their TSH levels, the difference of SOS between men with low-normal TSH and high-normal TSH contributed significantly to the association between TSH and bone health status (p<0.05). The significance of the association persisted with the inclusion and exclusion of subclinical hyperthyroid subjects. Conclusions: There was a significant association between TSH levels and bone health status in men as assessed by quantitative ultrasound. This age-independent association between TSH and SOS might explain some of the individual variation of bone health status in men.
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spelling pubmed-36754992013-06-18 Thyroid-Stimulating Hormone Is Significantly Associated with Bone Health Status in Men Chin, Kok-Yong Ima-Nirwana, Soelaiman Mohamed, Isa Naina Aminuddin, Amilia Johari, Mohamad Hanapi Ngah, Wan Zurinah Wan Int J Med Sci Research Paper Background and Aim: Recent studies revealed a novel association between thyroid-stimulating hormone (TSH) and bone health status in healthy male populations. The present study aimed to validate this association and provide new information on the relationship between TSH levels and calcaneal speed of sound (SOS) in men. Methods: This cross-sectional study recruited 681 men with complete data of calcaneal SOS, body anthropometry, serum TSH, free triiodothyronine (FT3) and free thyroxine (FT4) levels. Results: All subjects had FT3 and FT4 levels within the in-house reference range and 13 subjects had lower than normal TSH levels. The results revealed that the SOS value of subjects was significantly associated with TSH after multiple adjustments (p<0.05). When subjects were divided into quintiles according to their TSH levels, the difference of SOS between men with low-normal TSH and high-normal TSH contributed significantly to the association between TSH and bone health status (p<0.05). The significance of the association persisted with the inclusion and exclusion of subclinical hyperthyroid subjects. Conclusions: There was a significant association between TSH levels and bone health status in men as assessed by quantitative ultrasound. This age-independent association between TSH and SOS might explain some of the individual variation of bone health status in men. Ivyspring International Publisher 2013-05-14 /pmc/articles/PMC3675499/ /pubmed/23781131 http://dx.doi.org/10.7150/ijms.5870 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Research Paper
Chin, Kok-Yong
Ima-Nirwana, Soelaiman
Mohamed, Isa Naina
Aminuddin, Amilia
Johari, Mohamad Hanapi
Ngah, Wan Zurinah Wan
Thyroid-Stimulating Hormone Is Significantly Associated with Bone Health Status in Men
title Thyroid-Stimulating Hormone Is Significantly Associated with Bone Health Status in Men
title_full Thyroid-Stimulating Hormone Is Significantly Associated with Bone Health Status in Men
title_fullStr Thyroid-Stimulating Hormone Is Significantly Associated with Bone Health Status in Men
title_full_unstemmed Thyroid-Stimulating Hormone Is Significantly Associated with Bone Health Status in Men
title_short Thyroid-Stimulating Hormone Is Significantly Associated with Bone Health Status in Men
title_sort thyroid-stimulating hormone is significantly associated with bone health status in men
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675499/
https://www.ncbi.nlm.nih.gov/pubmed/23781131
http://dx.doi.org/10.7150/ijms.5870
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