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Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression

A hallmark of severe Lassa fever is the generalized immune suppression, the mechanism of which is poorly understood. Lassa virus (LASV) nucleoprotein (NP) is the only known 3′-5′ exoribonuclease that can suppress type I interferon (IFN) production possibly by degrading immune-stimulatory RNAs. How t...

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Detalles Bibliográficos
Autores principales:	Jiang, Xue, Huang, Qinfeng, Wang, Wenjian, Dong, Haohao, Ly, Hinh, Liang, Yuying, Dong, Changjiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675627/ https://www.ncbi.nlm.nih.gov/pubmed/23615902 http://dx.doi.org/10.1074/jbc.M112.420521

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