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Insights into the Activity and Specificity of Trypanosoma cruzi trans-Sialidase from Molecular Dynamics Simulations

[Image: see text] Trypanosoma cruzitrans-sialidase (TcTS), which catalyzes the transfer or hydrolysis of terminal sialic acid residues, is crucial to the development and proliferation of the T. cruzi parasite and thus has emerged as a potential drug target for the treatment of Chagas disease. We her...

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Detalles Bibliográficos
Autores principales:	Mitchell, Felicity L., Neres, João, Ramraj, Anitha, Raju, Rajesh K., Hillier, Ian H., Vincent, Mark A., Bryce, Richard A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2013
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675669/ https://www.ncbi.nlm.nih.gov/pubmed/23672572 http://dx.doi.org/10.1021/bi301112p

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