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Role of Gut Microbiota in Early Infant Development
Early colonization of the infant gastrointestinal tract is crucial for the overall health of the infant, and establishment and maintenance of non-pathogenic intestinal microbiota may reduce several neonatal inflammatory conditions. Much effort has therefore been devoted to manipulation of the compos...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676293/ https://www.ncbi.nlm.nih.gov/pubmed/23818794 |
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author | Wall, R Ross, R.P Ryan, C.A Hussey, S Murphy, B Fitzgerald, G.F Stanton, C |
author_facet | Wall, R Ross, R.P Ryan, C.A Hussey, S Murphy, B Fitzgerald, G.F Stanton, C |
author_sort | Wall, R |
collection | PubMed |
description | Early colonization of the infant gastrointestinal tract is crucial for the overall health of the infant, and establishment and maintenance of non-pathogenic intestinal microbiota may reduce several neonatal inflammatory conditions. Much effort has therefore been devoted to manipulation of the composition of the microbiota through 1) the role of early infant nutrition, particularly breast milk, and supplementation of infant formula with prebiotics that positively influence the enteric microbiota by selectively promoting growth of beneficial bacteria and 2) oral administration of probiotic bacteria which when administered in adequate amounts confer a health benefit on the host. While the complex microbiota of the adult is difficult to change in the long-term, there is greater impact of the diet on infant microbiota as this is not as stable as in adults. Decreasing excessive use of antibiotics and increasing the use of pre- and probiotics have shown to be beneficial in the prevention of several important infant diseases such as necrotizing enterocolitis and atopic eczema as well as improvement of short and long-term health. This review addresses how the composition of the gut microbiota becomes established in early life, its relevance to infant health, and dietary means by which it can be manipulated. |
format | Online Article Text |
id | pubmed-3676293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-36762932013-07-01 Role of Gut Microbiota in Early Infant Development Wall, R Ross, R.P Ryan, C.A Hussey, S Murphy, B Fitzgerald, G.F Stanton, C Clin Med Pediatr Review Early colonization of the infant gastrointestinal tract is crucial for the overall health of the infant, and establishment and maintenance of non-pathogenic intestinal microbiota may reduce several neonatal inflammatory conditions. Much effort has therefore been devoted to manipulation of the composition of the microbiota through 1) the role of early infant nutrition, particularly breast milk, and supplementation of infant formula with prebiotics that positively influence the enteric microbiota by selectively promoting growth of beneficial bacteria and 2) oral administration of probiotic bacteria which when administered in adequate amounts confer a health benefit on the host. While the complex microbiota of the adult is difficult to change in the long-term, there is greater impact of the diet on infant microbiota as this is not as stable as in adults. Decreasing excessive use of antibiotics and increasing the use of pre- and probiotics have shown to be beneficial in the prevention of several important infant diseases such as necrotizing enterocolitis and atopic eczema as well as improvement of short and long-term health. This review addresses how the composition of the gut microbiota becomes established in early life, its relevance to infant health, and dietary means by which it can be manipulated. Libertas Academica 2009-03-04 /pmc/articles/PMC3676293/ /pubmed/23818794 Text en © 2009 The authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Wall, R Ross, R.P Ryan, C.A Hussey, S Murphy, B Fitzgerald, G.F Stanton, C Role of Gut Microbiota in Early Infant Development |
title | Role of Gut Microbiota in Early Infant Development |
title_full | Role of Gut Microbiota in Early Infant Development |
title_fullStr | Role of Gut Microbiota in Early Infant Development |
title_full_unstemmed | Role of Gut Microbiota in Early Infant Development |
title_short | Role of Gut Microbiota in Early Infant Development |
title_sort | role of gut microbiota in early infant development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676293/ https://www.ncbi.nlm.nih.gov/pubmed/23818794 |
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