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Role of Gut Microbiota in Early Infant Development

Early colonization of the infant gastrointestinal tract is crucial for the overall health of the infant, and establishment and maintenance of non-pathogenic intestinal microbiota may reduce several neonatal inflammatory conditions. Much effort has therefore been devoted to manipulation of the compos...

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Detalles Bibliográficos
Autores principales: Wall, R, Ross, R.P, Ryan, C.A, Hussey, S, Murphy, B, Fitzgerald, G.F, Stanton, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676293/
https://www.ncbi.nlm.nih.gov/pubmed/23818794
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author Wall, R
Ross, R.P
Ryan, C.A
Hussey, S
Murphy, B
Fitzgerald, G.F
Stanton, C
author_facet Wall, R
Ross, R.P
Ryan, C.A
Hussey, S
Murphy, B
Fitzgerald, G.F
Stanton, C
author_sort Wall, R
collection PubMed
description Early colonization of the infant gastrointestinal tract is crucial for the overall health of the infant, and establishment and maintenance of non-pathogenic intestinal microbiota may reduce several neonatal inflammatory conditions. Much effort has therefore been devoted to manipulation of the composition of the microbiota through 1) the role of early infant nutrition, particularly breast milk, and supplementation of infant formula with prebiotics that positively influence the enteric microbiota by selectively promoting growth of beneficial bacteria and 2) oral administration of probiotic bacteria which when administered in adequate amounts confer a health benefit on the host. While the complex microbiota of the adult is difficult to change in the long-term, there is greater impact of the diet on infant microbiota as this is not as stable as in adults. Decreasing excessive use of antibiotics and increasing the use of pre- and probiotics have shown to be beneficial in the prevention of several important infant diseases such as necrotizing enterocolitis and atopic eczema as well as improvement of short and long-term health. This review addresses how the composition of the gut microbiota becomes established in early life, its relevance to infant health, and dietary means by which it can be manipulated.
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spelling pubmed-36762932013-07-01 Role of Gut Microbiota in Early Infant Development Wall, R Ross, R.P Ryan, C.A Hussey, S Murphy, B Fitzgerald, G.F Stanton, C Clin Med Pediatr Review Early colonization of the infant gastrointestinal tract is crucial for the overall health of the infant, and establishment and maintenance of non-pathogenic intestinal microbiota may reduce several neonatal inflammatory conditions. Much effort has therefore been devoted to manipulation of the composition of the microbiota through 1) the role of early infant nutrition, particularly breast milk, and supplementation of infant formula with prebiotics that positively influence the enteric microbiota by selectively promoting growth of beneficial bacteria and 2) oral administration of probiotic bacteria which when administered in adequate amounts confer a health benefit on the host. While the complex microbiota of the adult is difficult to change in the long-term, there is greater impact of the diet on infant microbiota as this is not as stable as in adults. Decreasing excessive use of antibiotics and increasing the use of pre- and probiotics have shown to be beneficial in the prevention of several important infant diseases such as necrotizing enterocolitis and atopic eczema as well as improvement of short and long-term health. This review addresses how the composition of the gut microbiota becomes established in early life, its relevance to infant health, and dietary means by which it can be manipulated. Libertas Academica 2009-03-04 /pmc/articles/PMC3676293/ /pubmed/23818794 Text en © 2009 The authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Wall, R
Ross, R.P
Ryan, C.A
Hussey, S
Murphy, B
Fitzgerald, G.F
Stanton, C
Role of Gut Microbiota in Early Infant Development
title Role of Gut Microbiota in Early Infant Development
title_full Role of Gut Microbiota in Early Infant Development
title_fullStr Role of Gut Microbiota in Early Infant Development
title_full_unstemmed Role of Gut Microbiota in Early Infant Development
title_short Role of Gut Microbiota in Early Infant Development
title_sort role of gut microbiota in early infant development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676293/
https://www.ncbi.nlm.nih.gov/pubmed/23818794
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