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Yi-Gan San Restores Behavioral Alterations and a Decrease of Brain Glutathione Level in a Mouse Model of Schizophrenia

The traditional Chinese herbal medicine yi-gan san has been used to cure neuropsychological disorders. Schizophrenia can be one of the target diseases of yi-gan san. We aimed at evaluating the possible use of yi-gan san in improving the schizophrenic symptoms of an animal model. Yi-gan san or distil...

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Autores principales: Makinodan, Manabu, Yamauchi, Takahira, Tatsumi, Kouko, Okuda, Hiroaki, Noriyama, Yoshinobu, Sadamatsu, Miyuki, Kishimoto, Toshifumi, Wanaka, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676319/
https://www.ncbi.nlm.nih.gov/pubmed/23818802
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author Makinodan, Manabu
Yamauchi, Takahira
Tatsumi, Kouko
Okuda, Hiroaki
Noriyama, Yoshinobu
Sadamatsu, Miyuki
Kishimoto, Toshifumi
Wanaka, Akio
author_facet Makinodan, Manabu
Yamauchi, Takahira
Tatsumi, Kouko
Okuda, Hiroaki
Noriyama, Yoshinobu
Sadamatsu, Miyuki
Kishimoto, Toshifumi
Wanaka, Akio
author_sort Makinodan, Manabu
collection PubMed
description The traditional Chinese herbal medicine yi-gan san has been used to cure neuropsychological disorders. Schizophrenia can be one of the target diseases of yi-gan san. We aimed at evaluating the possible use of yi-gan san in improving the schizophrenic symptoms of an animal model. Yi-gan san or distilled water was administered to mice born from pregnant mice injected with polyinosinic-polycytidilic acid or phosphate buffered saline. The former is a model of schizophrenia based on the epidemiological data that maternal infection leads to psychotic disorders including schizophrenia in the offspring. Prepulse inhibition and sensitivity to methamphetamine in open field tests were analyzed and the total glutathione content of whole brains was measured. Yi-gan san reversed the decrease in prepulse inhibition, hypersensitivity to methamphetamine and cognitive deficits found in the model mice to the level of control mice. Total glutathione content in whole brains was reduced in the model mice but was restored to normal levels by yi-gan san treatment. These results suggest that yi-gan san may have ameliorating effects on the pathological symptoms of schizophrenia.
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spelling pubmed-36763192013-07-01 Yi-Gan San Restores Behavioral Alterations and a Decrease of Brain Glutathione Level in a Mouse Model of Schizophrenia Makinodan, Manabu Yamauchi, Takahira Tatsumi, Kouko Okuda, Hiroaki Noriyama, Yoshinobu Sadamatsu, Miyuki Kishimoto, Toshifumi Wanaka, Akio J Brain Dis Original Research The traditional Chinese herbal medicine yi-gan san has been used to cure neuropsychological disorders. Schizophrenia can be one of the target diseases of yi-gan san. We aimed at evaluating the possible use of yi-gan san in improving the schizophrenic symptoms of an animal model. Yi-gan san or distilled water was administered to mice born from pregnant mice injected with polyinosinic-polycytidilic acid or phosphate buffered saline. The former is a model of schizophrenia based on the epidemiological data that maternal infection leads to psychotic disorders including schizophrenia in the offspring. Prepulse inhibition and sensitivity to methamphetamine in open field tests were analyzed and the total glutathione content of whole brains was measured. Yi-gan san reversed the decrease in prepulse inhibition, hypersensitivity to methamphetamine and cognitive deficits found in the model mice to the level of control mice. Total glutathione content in whole brains was reduced in the model mice but was restored to normal levels by yi-gan san treatment. These results suggest that yi-gan san may have ameliorating effects on the pathological symptoms of schizophrenia. Libertas Academica 2009-02-12 /pmc/articles/PMC3676319/ /pubmed/23818802 Text en © 2009 the author(s) This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://www.creativecommons.org/licenses/by/3.0/).
spellingShingle Original Research
Makinodan, Manabu
Yamauchi, Takahira
Tatsumi, Kouko
Okuda, Hiroaki
Noriyama, Yoshinobu
Sadamatsu, Miyuki
Kishimoto, Toshifumi
Wanaka, Akio
Yi-Gan San Restores Behavioral Alterations and a Decrease of Brain Glutathione Level in a Mouse Model of Schizophrenia
title Yi-Gan San Restores Behavioral Alterations and a Decrease of Brain Glutathione Level in a Mouse Model of Schizophrenia
title_full Yi-Gan San Restores Behavioral Alterations and a Decrease of Brain Glutathione Level in a Mouse Model of Schizophrenia
title_fullStr Yi-Gan San Restores Behavioral Alterations and a Decrease of Brain Glutathione Level in a Mouse Model of Schizophrenia
title_full_unstemmed Yi-Gan San Restores Behavioral Alterations and a Decrease of Brain Glutathione Level in a Mouse Model of Schizophrenia
title_short Yi-Gan San Restores Behavioral Alterations and a Decrease of Brain Glutathione Level in a Mouse Model of Schizophrenia
title_sort yi-gan san restores behavioral alterations and a decrease of brain glutathione level in a mouse model of schizophrenia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676319/
https://www.ncbi.nlm.nih.gov/pubmed/23818802
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