Toll Like Receptor 3 Plays a Critical Role in the Progression and Severity of Acetaminophen-Induced Hepatotoxicity

Toll-like receptor (TLR) activation has been implicated in acetaminophen (APAP)-induced hepatotoxicity. Herein, we hypothesize that TLR3 activation significantly contributed to APAP-induced liver injury. In fasted wildtype (WT) mice, APAP caused significant cellular necrosis, edema, and inflammation...

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Detalles Bibliográficos
Autores principales: Cavassani, Karen A., Moreira, Ana Paula, Habiel, David, Ito, Toshihiro, Coelho, Ana Lucia, Allen, Ron M., Hu, Bin, Raphelson, Janna, Carson, William F., Schaller, Matthew A., Lukacs, Nicholas W., Omary, M. Bishr, Hogaboam, Cory M., Kunkel, Steven L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676358/
https://www.ncbi.nlm.nih.gov/pubmed/23762449
http://dx.doi.org/10.1371/journal.pone.0065899

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