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Cytochrome P450 3A1 Mediates 2,2′,4,4′-Tetrabromodiphenyl Ether-Induced Reduction of Spermatogenesis in Adult Rats

BACKGROUND: 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) is the dominant PBDE congener in humans, wildlife, and the environment. It has been reported to be metabolized by cytochrome P450 (CYP) enzymes. Still, the effects of BDE47 on spermatogenesis failure are attracting an increasing amount of attent...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhan, Zhang, Xiaoming, Sun, Zhenzhen, Dong, Huibin, Qiu, Lianglin, Gu, Jun, Zhou, Jingping, Wang, Xinru, Wang, Shou-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676375/ https://www.ncbi.nlm.nih.gov/pubmed/23762486 http://dx.doi.org/10.1371/journal.pone.0066301

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