Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation

To identify rate-limiting steps in T cell-independent type 2 (TI-2) antibody production against polysaccharide antigens, we performed a genome-wide screen by immunizing several hundred pedigrees of C57BL/6 mice segregating ENU-induced mis-sense mutations. Two independent mutations, Tilcara and Untie...

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Detalles Bibliográficos
Autores principales: Teh, CE, Horikawa, K, Arnold, CN, Beutler, B, Kucharska, EM, Vinuesa, CG, Bertram, EM, Goodnow, CC, Enders, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676473/
https://www.ncbi.nlm.nih.gov/pubmed/23552399
http://dx.doi.org/10.1038/gene.2013.11

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