Inhibition of TGF–β signaling in subchondral bone mesenchymal stem cells attenuates osteoarthritis

Osteoarthritis is a highly prevalent and debilitating joint disorder. There is no effective medical therapy for osteoarthritis due to limited understanding of osteoarthritis pathogenesis. We show that TGF–β1 is activated in the subchondral bone in response to altered mechanical loading in an anterio...

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Detalles Bibliográficos
Autores principales: Zhen, Gehua, Wen, Chunyi, Jia, Xiaofeng, Li, Yu, Crane, Janet L., Mears, Simon C., Askin, Frederic B., Frassica, Frank J., Chang, Weizhong, Yao, Jie, Nayfeh, Tariq, Johnson, Carl, Artemov, Dmitri, Chen, Qianming, Zhao, Zhihe, Zhou, Xuedong, Cosgarea, Andrew, Carrino, John, Riley, Lee, Sponseller, Paul, Wan, Mei, Lu, William Weijia, Cao, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676689/
https://www.ncbi.nlm.nih.gov/pubmed/23685840
http://dx.doi.org/10.1038/nm.3143

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