Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity

Two new triterpenoids, 2α,3β-dihydroxyolean-11,13(18)-dien-19β,28-olide (1) and 3β,5β-dihydroxyglutinol (2), together with eight known compounds (3–10) were isolated from the roots of Rhaphiolepis indica var. tashiroi (Rosaceae). The structures of 1–10 were determined by spectroscopic techniques. Am...

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Autores principales: Lin, Chu-Hung, Chang, Hsun-Shuo, Liao, Hsiang-Ruei, Chen, Ih-Sheng, Tsai, Ian-Lih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676762/
https://www.ncbi.nlm.nih.gov/pubmed/23615476
http://dx.doi.org/10.3390/ijms14058890
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author Lin, Chu-Hung
Chang, Hsun-Shuo
Liao, Hsiang-Ruei
Chen, Ih-Sheng
Tsai, Ian-Lih
author_facet Lin, Chu-Hung
Chang, Hsun-Shuo
Liao, Hsiang-Ruei
Chen, Ih-Sheng
Tsai, Ian-Lih
author_sort Lin, Chu-Hung
collection PubMed
description Two new triterpenoids, 2α,3β-dihydroxyolean-11,13(18)-dien-19β,28-olide (1) and 3β,5β-dihydroxyglutinol (2), together with eight known compounds (3–10) were isolated from the roots of Rhaphiolepis indica var. tashiroi (Rosaceae). The structures of 1–10 were determined by spectroscopic techniques. Among these isolates, 2α,3β-dihydroxyolean-13(18)-en-28-oic acid (9) exhibited inhibitory effect on N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production, with an IC(50) value of 16.50 μM.
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spelling pubmed-36767622013-07-02 Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity Lin, Chu-Hung Chang, Hsun-Shuo Liao, Hsiang-Ruei Chen, Ih-Sheng Tsai, Ian-Lih Int J Mol Sci Article Two new triterpenoids, 2α,3β-dihydroxyolean-11,13(18)-dien-19β,28-olide (1) and 3β,5β-dihydroxyglutinol (2), together with eight known compounds (3–10) were isolated from the roots of Rhaphiolepis indica var. tashiroi (Rosaceae). The structures of 1–10 were determined by spectroscopic techniques. Among these isolates, 2α,3β-dihydroxyolean-13(18)-en-28-oic acid (9) exhibited inhibitory effect on N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production, with an IC(50) value of 16.50 μM. Molecular Diversity Preservation International (MDPI) 2013-04-24 /pmc/articles/PMC3676762/ /pubmed/23615476 http://dx.doi.org/10.3390/ijms14058890 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lin, Chu-Hung
Chang, Hsun-Shuo
Liao, Hsiang-Ruei
Chen, Ih-Sheng
Tsai, Ian-Lih
Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity
title Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity
title_full Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity
title_fullStr Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity
title_full_unstemmed Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity
title_short Triterpenoids from the Roots of Rhaphiolepis indica var. tashiroi and Their Anti-Inflammatory Activity
title_sort triterpenoids from the roots of rhaphiolepis indica var. tashiroi and their anti-inflammatory activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676762/
https://www.ncbi.nlm.nih.gov/pubmed/23615476
http://dx.doi.org/10.3390/ijms14058890
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