Melatonin-Based Therapeutics for Neuroprotection in Stroke

The present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In ad...

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Detalles Bibliográficos
Autores principales: Shinozuka, Kazutaka, Staples, Meaghan, Borlongan, Cesar V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676765/
https://www.ncbi.nlm.nih.gov/pubmed/23698756
http://dx.doi.org/10.3390/ijms14058924
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author Shinozuka, Kazutaka
Staples, Meaghan
Borlongan, Cesar V.
author_facet Shinozuka, Kazutaka
Staples, Meaghan
Borlongan, Cesar V.
author_sort Shinozuka, Kazutaka
collection PubMed
description The present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In addition, we describe a novel mechanism of action underlying the therapeutic benefits of stem cell therapy in stroke, implicating the role of melatonin receptors. As we envision the clinical entry of melatonin-based therapeutics, we discuss translational experiments that warrant consideration to reveal an optimal melatonin treatment strategy that is safe and effective for human application.
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spelling pubmed-36767652013-07-02 Melatonin-Based Therapeutics for Neuroprotection in Stroke Shinozuka, Kazutaka Staples, Meaghan Borlongan, Cesar V. Int J Mol Sci Review The present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In addition, we describe a novel mechanism of action underlying the therapeutic benefits of stem cell therapy in stroke, implicating the role of melatonin receptors. As we envision the clinical entry of melatonin-based therapeutics, we discuss translational experiments that warrant consideration to reveal an optimal melatonin treatment strategy that is safe and effective for human application. Molecular Diversity Preservation International (MDPI) 2013-04-25 /pmc/articles/PMC3676765/ /pubmed/23698756 http://dx.doi.org/10.3390/ijms14058924 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Shinozuka, Kazutaka
Staples, Meaghan
Borlongan, Cesar V.
Melatonin-Based Therapeutics for Neuroprotection in Stroke
title Melatonin-Based Therapeutics for Neuroprotection in Stroke
title_full Melatonin-Based Therapeutics for Neuroprotection in Stroke
title_fullStr Melatonin-Based Therapeutics for Neuroprotection in Stroke
title_full_unstemmed Melatonin-Based Therapeutics for Neuroprotection in Stroke
title_short Melatonin-Based Therapeutics for Neuroprotection in Stroke
title_sort melatonin-based therapeutics for neuroprotection in stroke
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676765/
https://www.ncbi.nlm.nih.gov/pubmed/23698756
http://dx.doi.org/10.3390/ijms14058924
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AT staplesmeaghan melatoninbasedtherapeuticsforneuroprotectioninstroke
AT borlongancesarv melatoninbasedtherapeuticsforneuroprotectioninstroke

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