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Molecular Dynamics Simulation of Tryptophan Hydroxylase-1: Binding Modes and Free Energy Analysis to Phenylalanine Derivative Inhibitors

Serotonin is a neurotransmitter that modulates many central and peripheral functions. Tryptophan hydroxylase-1 (TPH1) is a key enzyme of serotonin synthesis. In the current study, the interaction mechanism of phenylalanine derivative TPH1 inhibitors was investigated using molecular dynamics (MD) sim...

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Detalles Bibliográficos
Autores principales:	Zhong, Hao, Huang, Wei, He, Gu, Peng, Cheng, Wu, Fengbo, Ouyang, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676822/ https://www.ncbi.nlm.nih.gov/pubmed/23665899 http://dx.doi.org/10.3390/ijms14059947

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