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Genome-Wide Gene Expression Profiles in Antioxidant Pathways and Their Potential Sex Differences and Connections to Vitamin C in Mice

Vitamin C (VC) is well known as an antioxidant in humans, primates and guinea pigs. Studies have suggested gender differences in VC requirements in humans, and gender differences in oxidant injury vulnerability in early life may represent a biological mechanism contributing to gender disparity in la...

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Autores principales: Jiao, Yan, Chen, Hong, Yan, Jian, Wang, Lishi, Huang, Yue, Liu, Xiaoyun, Williams, Robert W., Lu, Lu, Wang, Yongjun, Gu, Weikuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676827/
https://www.ncbi.nlm.nih.gov/pubmed/23665904
http://dx.doi.org/10.3390/ijms140510042
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author Jiao, Yan
Chen, Hong
Yan, Jian
Wang, Lishi
Huang, Yue
Liu, Xiaoyun
Williams, Robert W.
Lu, Lu
Wang, Yongjun
Gu, Weikuan
author_facet Jiao, Yan
Chen, Hong
Yan, Jian
Wang, Lishi
Huang, Yue
Liu, Xiaoyun
Williams, Robert W.
Lu, Lu
Wang, Yongjun
Gu, Weikuan
author_sort Jiao, Yan
collection PubMed
description Vitamin C (VC) is well known as an antioxidant in humans, primates and guinea pigs. Studies have suggested gender differences in VC requirements in humans, and gender differences in oxidant injury vulnerability in early life may represent a biological mechanism contributing to gender disparity in later life. Using spontaneous bone fracture (sfx) mice, which lack the gene for L-Gulonolactone oxidase (Gulo), we studied the potential sex difference in expression profiles of oxidative genes at the whole-genome level. Then, we analyzed data of gene expressions in a mouse population of recombinant inbred (RI) strains originally derived by crossing C57BL/6J (B6) and DBA/2J (D2) mice. Our data indicated that there were sex differences in the regulation of pre- and pro-oxidative genes in sfx mice. The associations of expression levels among Gulo, its partner genes and oxidative genes in the BXD (B6 × D2) RI strains showed a sex difference. Transcriptome mapping suggests that Gulo was regulated differently between female and male mice in BXD RI strains. Our study indicates the importance of investigating sex differences in Gulo and its oxidative function by using available mouse models.
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spelling pubmed-36768272013-07-02 Genome-Wide Gene Expression Profiles in Antioxidant Pathways and Their Potential Sex Differences and Connections to Vitamin C in Mice Jiao, Yan Chen, Hong Yan, Jian Wang, Lishi Huang, Yue Liu, Xiaoyun Williams, Robert W. Lu, Lu Wang, Yongjun Gu, Weikuan Int J Mol Sci Article Vitamin C (VC) is well known as an antioxidant in humans, primates and guinea pigs. Studies have suggested gender differences in VC requirements in humans, and gender differences in oxidant injury vulnerability in early life may represent a biological mechanism contributing to gender disparity in later life. Using spontaneous bone fracture (sfx) mice, which lack the gene for L-Gulonolactone oxidase (Gulo), we studied the potential sex difference in expression profiles of oxidative genes at the whole-genome level. Then, we analyzed data of gene expressions in a mouse population of recombinant inbred (RI) strains originally derived by crossing C57BL/6J (B6) and DBA/2J (D2) mice. Our data indicated that there were sex differences in the regulation of pre- and pro-oxidative genes in sfx mice. The associations of expression levels among Gulo, its partner genes and oxidative genes in the BXD (B6 × D2) RI strains showed a sex difference. Transcriptome mapping suggests that Gulo was regulated differently between female and male mice in BXD RI strains. Our study indicates the importance of investigating sex differences in Gulo and its oxidative function by using available mouse models. Molecular Diversity Preservation International (MDPI) 2013-05-10 /pmc/articles/PMC3676827/ /pubmed/23665904 http://dx.doi.org/10.3390/ijms140510042 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Jiao, Yan
Chen, Hong
Yan, Jian
Wang, Lishi
Huang, Yue
Liu, Xiaoyun
Williams, Robert W.
Lu, Lu
Wang, Yongjun
Gu, Weikuan
Genome-Wide Gene Expression Profiles in Antioxidant Pathways and Their Potential Sex Differences and Connections to Vitamin C in Mice
title Genome-Wide Gene Expression Profiles in Antioxidant Pathways and Their Potential Sex Differences and Connections to Vitamin C in Mice
title_full Genome-Wide Gene Expression Profiles in Antioxidant Pathways and Their Potential Sex Differences and Connections to Vitamin C in Mice
title_fullStr Genome-Wide Gene Expression Profiles in Antioxidant Pathways and Their Potential Sex Differences and Connections to Vitamin C in Mice
title_full_unstemmed Genome-Wide Gene Expression Profiles in Antioxidant Pathways and Their Potential Sex Differences and Connections to Vitamin C in Mice
title_short Genome-Wide Gene Expression Profiles in Antioxidant Pathways and Their Potential Sex Differences and Connections to Vitamin C in Mice
title_sort genome-wide gene expression profiles in antioxidant pathways and their potential sex differences and connections to vitamin c in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676827/
https://www.ncbi.nlm.nih.gov/pubmed/23665904
http://dx.doi.org/10.3390/ijms140510042
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