Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection

Epigenetic alterations including DNA methylation and microRNAs (miRNAs) play important roles in the initiation and progression of human cancers. As the extensively studied epigenetic changes in tumors, DNA methylation and miRNAs are the most potential epigenetic biomarkers for cancer diagnosis. Afte...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Yanning, Wang, Xian, Jin, Hongchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676840/
https://www.ncbi.nlm.nih.gov/pubmed/23681012
http://dx.doi.org/10.3390/ijms140510307
_version_ 1782272678016581632
author Ma, Yanning
Wang, Xian
Jin, Hongchuan
author_facet Ma, Yanning
Wang, Xian
Jin, Hongchuan
author_sort Ma, Yanning
collection PubMed
description Epigenetic alterations including DNA methylation and microRNAs (miRNAs) play important roles in the initiation and progression of human cancers. As the extensively studied epigenetic changes in tumors, DNA methylation and miRNAs are the most potential epigenetic biomarkers for cancer diagnosis. After the identification of circulating cell-free nuclear acids, increasing evidence demonstrated great potential of cell-free epigenetic biomarkers in the blood or other body fluids for cancer detection.
format Online
Article
Text
id pubmed-3676840
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-36768402013-07-02 Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection Ma, Yanning Wang, Xian Jin, Hongchuan Int J Mol Sci Review Epigenetic alterations including DNA methylation and microRNAs (miRNAs) play important roles in the initiation and progression of human cancers. As the extensively studied epigenetic changes in tumors, DNA methylation and miRNAs are the most potential epigenetic biomarkers for cancer diagnosis. After the identification of circulating cell-free nuclear acids, increasing evidence demonstrated great potential of cell-free epigenetic biomarkers in the blood or other body fluids for cancer detection. Molecular Diversity Preservation International (MDPI) 2013-05-16 /pmc/articles/PMC3676840/ /pubmed/23681012 http://dx.doi.org/10.3390/ijms140510307 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Ma, Yanning
Wang, Xian
Jin, Hongchuan
Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection
title Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection
title_full Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection
title_fullStr Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection
title_full_unstemmed Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection
title_short Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection
title_sort methylated dna and microrna in body fluids as biomarkers for cancer detection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676840/
https://www.ncbi.nlm.nih.gov/pubmed/23681012
http://dx.doi.org/10.3390/ijms140510307
work_keys_str_mv AT mayanning methylateddnaandmicrornainbodyfluidsasbiomarkersforcancerdetection
AT wangxian methylateddnaandmicrornainbodyfluidsasbiomarkersforcancerdetection
AT jinhongchuan methylateddnaandmicrornainbodyfluidsasbiomarkersforcancerdetection

Ejemplares similares