NRF2 Protection against Liver Injury Produced by Various Hepatotoxicants

To investigate the role of Nrf2 as a master defense against the hepatotoxicity produced by various chemicals, Nrf2-null, wild-type, Keap1-knock down (Keap1-Kd) and Keap1-hepatocyte knockout (Keap1-HKO) mice were used as a “graded Nrf2 activation” model. Mice were treated with 14 hepatotoxicants at a...

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Detalles Bibliográficos
Autores principales: Liu, Jie, Wu, Kai Connie, Lu, Yuan-Fu, Ekuase, Edugie, Klaassen, Curtis D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676920/
https://www.ncbi.nlm.nih.gov/pubmed/23766851
http://dx.doi.org/10.1155/2013/305861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676920/
https://www.ncbi.nlm.nih.gov/pubmed/23766851
http://dx.doi.org/10.1155/2013/305861

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