Adaptive Immunity, Inflammation, and Cardiovascular Complications in Type 1 and Type 2 Diabetes Mellitus

Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β-cells mediated by autoreacti...

Descripción completa

Detalles Bibliográficos
Autores principales: Pedicino, Daniela, Liuzzo, Giovanna, Trotta, Francesco, Giglio, Ada Francesca, Giubilato, Simona, Martini, Francesca, Zaccardi, Francesco, Scavone, Giuseppe, Previtero, Marco, Massaro, Gianluca, Cialdella, Pio, Cardillo, Maria Teresa, Pitocco, Dario, Ghirlanda, Giovanni, Crea, Filippo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676957/
https://www.ncbi.nlm.nih.gov/pubmed/23762872
http://dx.doi.org/10.1155/2013/184258
Descripción
Sumario:Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β-cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β-cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.

Ejemplares similares