Cargando…

Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α

Increased levels of hypoxia and hypoxia-inducible factor 1α (HIF-1α) in human sarcomas correlate with tumor progression and radiation resistance. Prolonged antiangiogenic therapy of tumors not only delays tumor growth but may also increase hypoxia and HIF-1α activity. In our recent clinical trial, t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Yeo-Jung, Lee, Hae-June, Kim, Tae-Min, Eisinger-Mathason, TS Karin, Zhang, Alexia Y, Schmidt, Benjamin, Karl, Daniel L, Nakazawa, Michael S, Park, Peter J, Simon, M Celeste, Yoon, Sam S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wiley Subscription Services, Inc., A Wiley Company 2013
Materias:	Cancer Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677782/ https://www.ncbi.nlm.nih.gov/pubmed/22684860 http://dx.doi.org/10.1002/ijc.27666

Ejemplares similares

Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth
por: Nakazawa, Michael S., et al.
Publicado: (2016)

Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas
por: Yoon, C, et al.
Publicado: (2015)

Context Matters: Response Heterogeneity to Collagen-Targeting Approaches in Desmoplastic Cancers
por: Fuller, Ashley M., et al.
Publicado: (2022)

Inhibition of hypoxia-inducible factor 1α accumulation by glyceryl trinitrate and cyclic guanosine monophosphate
por: Kim, Judy, et al.
Publicado: (2020)

Overcoming Immune Evasion in Melanoma
por: Eddy, Kevinn, et al.
Publicado: (2020)

TRPM8 facilitates proliferation and immune evasion of esophageal cancer cells
por: Lan, Xinyan, et al.
Publicado: (2019)

MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma
por: Mucaj, Vera, et al.
Publicado: (2014)

Epidemiological study of soft‐tissue sarcomas in Ireland
por: Bhatt, Nikita, et al.
Publicado: (2015)

Overcoming tumor immune evasion with an unique arbovirus
por: Lyday, Bruce, et al.
Publicado: (2015)

Hypoxia-inducible factor underlies von Hippel-Lindau disease stigmata
por: Ohh, Michael, et al.
Publicado: (2022)

Overcoming Linsitinib intrinsic resistance through inhibition of nuclear factor‐κB signaling in esophageal squamous cell carcinoma
por: Wu, Junzhou, et al.
Publicado: (2017)

The out-of-field dose in radiation therapy induces delayed tumorigenesis by senescence evasion
por: Goy, Erwan, et al.
Publicado: (2022)

Is fluoride a risk factor for bone cancer? Small area analysis of osteosarcoma and Ewing sarcoma diagnosed among 0–49-year-olds in Great Britain, 1980–2005
por: Blakey, Karen, et al.
Publicado: (2014)

Expression significance and potential mechanism of hypoxia‐inducible factor 1 alpha in patients with myelodysplastic syndromes
por: Liang, Hai‐wei, et al.
Publicado: (2019)

Parkin Deficiency Suppresses Antigen Presentation to Promote Tumor Immune Evasion and Immunotherapy Resistance
por: Perales-Linares, Renzo, et al.
Publicado: (2023)

Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
por: Deng, Qu, et al.
Publicado: (2022)

Hypoxia‐inducible factor 1 promotes chemoresistance of lung cancer by inducing carbonic anhydrase IX expression
por: Sowa, Terumasa, et al.
Publicado: (2016)

Mechanisms of immune evasion and current status of checkpoint inhibitors in non‐small cell lung cancer
por: Qin, Angel, et al.
Publicado: (2016)

Complement evasion factor (CEF), a novel immune evasion factor of Streptococcus pyogenes
por: Aghababa, Haniyeh, et al.
Publicado: (2022)

Hypoxia-inducible factor-2α regulates the expression of TRAIL receptor DR5 in renal cancer cells
por: Mahajan, S., et al.
Publicado: (2008)

Overcoming cisplatin resistance in osteosarcoma through the miR-199a-modulated inhibition of HIF-1α
por: Keremu, Ajimu, et al.
Publicado: (2019)

Isolated limb perfusion with biochemotherapy and oncolytic virotherapy combines with radiotherapy and surgery to overcome treatment resistance in an animal model of extremity soft tissue sarcoma
por: Wilkinson, Michelle J., et al.
Publicado: (2016)

Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor
por: Knowles, Helen J, et al.
Publicado: (2010)

Optimal cancer evasion in a dynamic immune microenvironment generates diverse post-escape tumor antigenicity profiles
por: George, Jason T, et al.
Publicado: (2023)

Reversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies
por: Ratnam, Nivedita M., et al.
Publicado: (2021)

TAE226, a dual inhibitor of focal adhesion kinase and insulin‐like growth factor‐I receptor, is effective for Ewing sarcoma
por: Moritake, Hiroshi, et al.
Publicado: (2019)

A hypoxia-related prognostic model predicts overall survival and treatment response in hepatocellular carcinoma
por: Xing, Jiyuan, et al.
Publicado: (2022)

Wnt/β-catenin signaling as an emerging potential key pharmacological target in cholangiocarcinoma
por: Zhang, Guo-Feng, et al.
Publicado: (2020)

Hypoxia-induced up-regulation of miR-27a promotes paclitaxel resistance in ovarian cancer
por: Feng, Lanlan, et al.
Publicado: (2020)

Hypoxia-induced PTTG3P contributes to colorectal cancer glycolysis and M2 phenotype of macrophage
por: Wang, Yue, et al.
Publicado: (2021)

The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma
por: Park, Eun‐Ran, et al.
Publicado: (2017)

Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors
por: Chen, Yunching, et al.
Publicado: (2017)

Triple Immunotherapy Overcomes Immune Evasion by Tumor in a Melanoma Mouse Model
por: Jallad, Mary-Ann N., et al.
Publicado: (2020)

Plasma cupping induces VEGF expression in skin cells through nitric oxide-mediated activation of hypoxia inducible factor 1
por: Lee, Hyun-Young, et al.
Publicado: (2019)

Exploring the mechanism of aidi injection for lung cancer by network pharmacology approach and molecular docking validation
por: Zhuang, Zhenjie, et al.
Publicado: (2021)

Hypoxia‐inducible factor 1A inhibition overcomes castration resistance of prostate tumors
por: Terzic, Julie, et al.
Publicado: (2023)

Epithelial–mesenchymal transition and its transcription factors
por: Debnath, Pallabi, et al.
Publicado: (2021)

Transforming growth factor-β(1) induces connective tissue growth factor expression and promotes peritoneal metastasis of gastric cancer
por: Lv, Ling, et al.
Publicado: (2020)

Clathrin‐mediated EGFR endocytosis as a potential therapeutic strategy for overcoming primary resistance of EGFR TKI in wild‐type EGFR non‐small cell lung cancer
por: Kim, Boyeon, et al.
Publicado: (2020)

Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
por: Mulcahy Levy, Jean M, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_e6m5tbb1bckto4g138fbj2369d