Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis

We performed a genome-wide association study in non-Hispanic white subjects with fibrotic idiopathic interstitial pneumonias (N=1616) and controls (N=4683); replication was assessed in 876 cases and 1890 controls. We confirmed association with TERT and MUC5B on chromosomes 5p15 and 11p15, respective...

Descripción completa

Detalles Bibliográficos
Autores principales: Fingerlin, Tasha E., Murphy, Elissa, Zhang, Weiming, Peljto, Anna L., Brown, Kevin K., Steele, Mark P., Loyd, James E., Cosgrove, Gregory P., Lynch, David, Groshong, Steve, Collard, Harold R., Wolters, Paul J., Bradford, Williamson Z., Kossen, Karl, Seiwert, Scott D., du Bois, Roland M., Garcia, Christine Kim, Devine, Megan S., Gudmundsson, Gunnar, Isaksson, Helgi J., Kaminski, Naftali, Zhang, Yingze, Gibson, Kevin F., Lancaster, Lisa H., Cogan, Joy D., Mason, Wendi R., Maher, Toby M., Molyneaux, Philip L., Wells, Athol U., Moffatt, Miriam F., Selman, Moises, Pardo, Annie, Kim, Dong Soon, Crapo, James D., Make, Barry J., Regan, Elizabeth A., Walek, Dinesha S., Daniel, Jerry J., Kamatani, Yoichiro, Zelenika, Diana, Smith, Keith, McKean, David, Pedersen, Brent S., Talbert, Janet, Kidd, Ravin N., Markin, Cheryl R., Beckman, Kenneth B., Lathrop, Mark, Schwarz, Marvin I., Schwartz, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677861/
https://www.ncbi.nlm.nih.gov/pubmed/23583980
http://dx.doi.org/10.1038/ng.2609
_version_ 1782272765485645824
author Fingerlin, Tasha E.
Murphy, Elissa
Zhang, Weiming
Peljto, Anna L.
Brown, Kevin K.
Steele, Mark P.
Loyd, James E.
Cosgrove, Gregory P.
Lynch, David
Groshong, Steve
Collard, Harold R.
Wolters, Paul J.
Bradford, Williamson Z.
Kossen, Karl
Seiwert, Scott D.
du Bois, Roland M.
Garcia, Christine Kim
Devine, Megan S.
Gudmundsson, Gunnar
Isaksson, Helgi J.
Kaminski, Naftali
Zhang, Yingze
Gibson, Kevin F.
Lancaster, Lisa H.
Cogan, Joy D.
Mason, Wendi R.
Maher, Toby M.
Molyneaux, Philip L.
Wells, Athol U.
Moffatt, Miriam F.
Selman, Moises
Pardo, Annie
Kim, Dong Soon
Crapo, James D.
Make, Barry J.
Regan, Elizabeth A.
Walek, Dinesha S.
Daniel, Jerry J.
Kamatani, Yoichiro
Zelenika, Diana
Smith, Keith
McKean, David
Pedersen, Brent S.
Talbert, Janet
Kidd, Ravin N.
Markin, Cheryl R.
Beckman, Kenneth B.
Lathrop, Mark
Schwarz, Marvin I.
Schwartz, David A.
author_facet Fingerlin, Tasha E.
Murphy, Elissa
Zhang, Weiming
Peljto, Anna L.
Brown, Kevin K.
Steele, Mark P.
Loyd, James E.
Cosgrove, Gregory P.
Lynch, David
Groshong, Steve
Collard, Harold R.
Wolters, Paul J.
Bradford, Williamson Z.
Kossen, Karl
Seiwert, Scott D.
du Bois, Roland M.
Garcia, Christine Kim
Devine, Megan S.
Gudmundsson, Gunnar
Isaksson, Helgi J.
Kaminski, Naftali
Zhang, Yingze
Gibson, Kevin F.
Lancaster, Lisa H.
Cogan, Joy D.
Mason, Wendi R.
Maher, Toby M.
Molyneaux, Philip L.
Wells, Athol U.
Moffatt, Miriam F.
Selman, Moises
Pardo, Annie
Kim, Dong Soon
Crapo, James D.
Make, Barry J.
Regan, Elizabeth A.
Walek, Dinesha S.
Daniel, Jerry J.
Kamatani, Yoichiro
Zelenika, Diana
Smith, Keith
McKean, David
Pedersen, Brent S.
Talbert, Janet
Kidd, Ravin N.
Markin, Cheryl R.
Beckman, Kenneth B.
Lathrop, Mark
Schwarz, Marvin I.
Schwartz, David A.
author_sort Fingerlin, Tasha E.
collection PubMed
description We performed a genome-wide association study in non-Hispanic white subjects with fibrotic idiopathic interstitial pneumonias (N=1616) and controls (N=4683); replication was assessed in 876 cases and 1890 controls. We confirmed association with TERT and MUC5B on chromosomes 5p15 and 11p15, respectively, the chromosome 3q26 region near TERC, and identified 7 novel loci (P(Meta) = 2.4×10(−8) to P(Meta) = 1.1×10(−19)). The novel loci include FAM13A (4q22), DSP (6p24), OBFC1 (10q24), ATP11A (13q34), DPP9 (19p13), and chromosomal regions 7q22 and 15q14-15. Our results demonstrate that genes involved in host defense, cell-cell adhesion, and DNA repair contribute to the risk of fibrotic IIP.
format Online
Article
Text
id pubmed-3677861
institution National Center for Biotechnology Information
language English
publishDate 2013
record_format MEDLINE/PubMed
spelling pubmed-36778612013-12-01 Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis Fingerlin, Tasha E. Murphy, Elissa Zhang, Weiming Peljto, Anna L. Brown, Kevin K. Steele, Mark P. Loyd, James E. Cosgrove, Gregory P. Lynch, David Groshong, Steve Collard, Harold R. Wolters, Paul J. Bradford, Williamson Z. Kossen, Karl Seiwert, Scott D. du Bois, Roland M. Garcia, Christine Kim Devine, Megan S. Gudmundsson, Gunnar Isaksson, Helgi J. Kaminski, Naftali Zhang, Yingze Gibson, Kevin F. Lancaster, Lisa H. Cogan, Joy D. Mason, Wendi R. Maher, Toby M. Molyneaux, Philip L. Wells, Athol U. Moffatt, Miriam F. Selman, Moises Pardo, Annie Kim, Dong Soon Crapo, James D. Make, Barry J. Regan, Elizabeth A. Walek, Dinesha S. Daniel, Jerry J. Kamatani, Yoichiro Zelenika, Diana Smith, Keith McKean, David Pedersen, Brent S. Talbert, Janet Kidd, Ravin N. Markin, Cheryl R. Beckman, Kenneth B. Lathrop, Mark Schwarz, Marvin I. Schwartz, David A. Nat Genet Article We performed a genome-wide association study in non-Hispanic white subjects with fibrotic idiopathic interstitial pneumonias (N=1616) and controls (N=4683); replication was assessed in 876 cases and 1890 controls. We confirmed association with TERT and MUC5B on chromosomes 5p15 and 11p15, respectively, the chromosome 3q26 region near TERC, and identified 7 novel loci (P(Meta) = 2.4×10(−8) to P(Meta) = 1.1×10(−19)). The novel loci include FAM13A (4q22), DSP (6p24), OBFC1 (10q24), ATP11A (13q34), DPP9 (19p13), and chromosomal regions 7q22 and 15q14-15. Our results demonstrate that genes involved in host defense, cell-cell adhesion, and DNA repair contribute to the risk of fibrotic IIP. 2013-04-14 2013-06 /pmc/articles/PMC3677861/ /pubmed/23583980 http://dx.doi.org/10.1038/ng.2609 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Fingerlin, Tasha E.
Murphy, Elissa
Zhang, Weiming
Peljto, Anna L.
Brown, Kevin K.
Steele, Mark P.
Loyd, James E.
Cosgrove, Gregory P.
Lynch, David
Groshong, Steve
Collard, Harold R.
Wolters, Paul J.
Bradford, Williamson Z.
Kossen, Karl
Seiwert, Scott D.
du Bois, Roland M.
Garcia, Christine Kim
Devine, Megan S.
Gudmundsson, Gunnar
Isaksson, Helgi J.
Kaminski, Naftali
Zhang, Yingze
Gibson, Kevin F.
Lancaster, Lisa H.
Cogan, Joy D.
Mason, Wendi R.
Maher, Toby M.
Molyneaux, Philip L.
Wells, Athol U.
Moffatt, Miriam F.
Selman, Moises
Pardo, Annie
Kim, Dong Soon
Crapo, James D.
Make, Barry J.
Regan, Elizabeth A.
Walek, Dinesha S.
Daniel, Jerry J.
Kamatani, Yoichiro
Zelenika, Diana
Smith, Keith
McKean, David
Pedersen, Brent S.
Talbert, Janet
Kidd, Ravin N.
Markin, Cheryl R.
Beckman, Kenneth B.
Lathrop, Mark
Schwarz, Marvin I.
Schwartz, David A.
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
title Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
title_full Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
title_fullStr Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
title_full_unstemmed Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
title_short Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
title_sort genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677861/
https://www.ncbi.nlm.nih.gov/pubmed/23583980
http://dx.doi.org/10.1038/ng.2609
work_keys_str_mv AT fingerlintashae genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT murphyelissa genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT zhangweiming genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT peljtoannal genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT brownkevink genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT steelemarkp genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT loydjamese genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT cosgrovegregoryp genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT lynchdavid genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT groshongsteve genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT collardharoldr genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT wolterspaulj genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT bradfordwilliamsonz genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT kossenkarl genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT seiwertscottd genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT duboisrolandm genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT garciachristinekim genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT devinemegans genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT gudmundssongunnar genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT isakssonhelgij genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT kaminskinaftali genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT zhangyingze genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT gibsonkevinf genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT lancasterlisah genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT coganjoyd genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT masonwendir genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT mahertobym genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT molyneauxphilipl genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT wellsatholu genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT moffattmiriamf genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT selmanmoises genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT pardoannie genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT kimdongsoon genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT crapojamesd genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT makebarryj genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT reganelizabetha genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT walekdineshas genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT danieljerryj genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT kamataniyoichiro genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT zelenikadiana genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT smithkeith genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT mckeandavid genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT pedersenbrents genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT talbertjanet genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT kiddravinn genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT markincherylr genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT beckmankennethb genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT lathropmark genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT schwarzmarvini genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis
AT schwartzdavida genomewideassociationstudyidentifiesmultiplesusceptibilitylociforpulmonaryfibrosis

Ejemplares similares