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Information Exploration System for Sickle Cell Disease and Repurposing of Hydroxyfasudil

BACKGROUND: Sickle cell disease (SCD) is a fatal monogenic disorder with no effective cure and thus high rates of morbidity and sequelae. Efforts toward discovery of disease modifying drugs and curative strategies can be augmented by leveraging the plethora of information contained in available biom...

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Autores principales: Essack, Magbubah, Radovanovic, Aleksandar, Bajic, Vladimir B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677893/
https://www.ncbi.nlm.nih.gov/pubmed/23762313
http://dx.doi.org/10.1371/journal.pone.0065190
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author Essack, Magbubah
Radovanovic, Aleksandar
Bajic, Vladimir B.
author_facet Essack, Magbubah
Radovanovic, Aleksandar
Bajic, Vladimir B.
author_sort Essack, Magbubah
collection PubMed
description BACKGROUND: Sickle cell disease (SCD) is a fatal monogenic disorder with no effective cure and thus high rates of morbidity and sequelae. Efforts toward discovery of disease modifying drugs and curative strategies can be augmented by leveraging the plethora of information contained in available biomedical literature. To facilitate research in this direction we have developed a resource, Dragon Exploration System for Sickle Cell Disease (DESSCD) (http://cbrc.kaust.edu.sa/desscd/) that aims to promote the easy exploration of SCD-related data. DESCRIPTION: The Dragon Exploration System (DES), developed based on text mining and complemented by data mining, processed 419,612 MEDLINE abstracts retrieved from a PubMed query using SCD-related keywords. The processed SCD-related data has been made available via the DESSCD web query interface that enables: a/information retrieval using specified concepts, keywords and phrases, and b/the generation of inferred association networks and hypotheses. The usefulness of the system is demonstrated by: a/reproducing a known scientific fact, the “Sickle_Cell_Anemia–Hydroxyurea” association, and b/generating novel and plausible “Sickle_Cell_Anemia–Hydroxyfasudil” hypothesis. A PCT patent (PCT/US12/55042) has been filed for the latter drug repurposing for SCD treatment. CONCLUSION: We developed the DESSCD resource dedicated to exploration of text-mined and data-mined information about SCD. No similar SCD-related resource exists. Thus, we anticipate that DESSCD will serve as a valuable tool for physicians and researchers interested in SCD.
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spelling pubmed-36778932013-06-12 Information Exploration System for Sickle Cell Disease and Repurposing of Hydroxyfasudil Essack, Magbubah Radovanovic, Aleksandar Bajic, Vladimir B. PLoS One Research Article BACKGROUND: Sickle cell disease (SCD) is a fatal monogenic disorder with no effective cure and thus high rates of morbidity and sequelae. Efforts toward discovery of disease modifying drugs and curative strategies can be augmented by leveraging the plethora of information contained in available biomedical literature. To facilitate research in this direction we have developed a resource, Dragon Exploration System for Sickle Cell Disease (DESSCD) (http://cbrc.kaust.edu.sa/desscd/) that aims to promote the easy exploration of SCD-related data. DESCRIPTION: The Dragon Exploration System (DES), developed based on text mining and complemented by data mining, processed 419,612 MEDLINE abstracts retrieved from a PubMed query using SCD-related keywords. The processed SCD-related data has been made available via the DESSCD web query interface that enables: a/information retrieval using specified concepts, keywords and phrases, and b/the generation of inferred association networks and hypotheses. The usefulness of the system is demonstrated by: a/reproducing a known scientific fact, the “Sickle_Cell_Anemia–Hydroxyurea” association, and b/generating novel and plausible “Sickle_Cell_Anemia–Hydroxyfasudil” hypothesis. A PCT patent (PCT/US12/55042) has been filed for the latter drug repurposing for SCD treatment. CONCLUSION: We developed the DESSCD resource dedicated to exploration of text-mined and data-mined information about SCD. No similar SCD-related resource exists. Thus, we anticipate that DESSCD will serve as a valuable tool for physicians and researchers interested in SCD. Public Library of Science 2013-06-10 /pmc/articles/PMC3677893/ /pubmed/23762313 http://dx.doi.org/10.1371/journal.pone.0065190 Text en © 2013 Essack et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Essack, Magbubah
Radovanovic, Aleksandar
Bajic, Vladimir B.
Information Exploration System for Sickle Cell Disease and Repurposing of Hydroxyfasudil
title Information Exploration System for Sickle Cell Disease and Repurposing of Hydroxyfasudil
title_full Information Exploration System for Sickle Cell Disease and Repurposing of Hydroxyfasudil
title_fullStr Information Exploration System for Sickle Cell Disease and Repurposing of Hydroxyfasudil
title_full_unstemmed Information Exploration System for Sickle Cell Disease and Repurposing of Hydroxyfasudil
title_short Information Exploration System for Sickle Cell Disease and Repurposing of Hydroxyfasudil
title_sort information exploration system for sickle cell disease and repurposing of hydroxyfasudil
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677893/
https://www.ncbi.nlm.nih.gov/pubmed/23762313
http://dx.doi.org/10.1371/journal.pone.0065190
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