Combined 5-FU and ChoKα Inhibitors as a New Alternative Therapy of Colorectal Cancer: Evidence in Human Tumor-Derived Cell Lines and Mouse Xenografts

BACKGROUND: Colorectal cancer (CRC) is the third major cause of cancer related deaths in the world. 5-fluorouracil (5-FU) is widely used for the treatment of colorectal cancer but as a single-agent renders low response rates. Choline kinase alpha (ChoKα), an enzyme that plays a role in cell prolifer...

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Detalles Bibliográficos
Autores principales: de la Cueva, Ana, Ramírez de Molina, Ana, Álvarez-Ayerza, Néstor, Ramos, Ma Angeles, Cebrián, Arancha, del Pulgar, Teresa Gómez, Lacal, Juan Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677921/
https://www.ncbi.nlm.nih.gov/pubmed/23762272
http://dx.doi.org/10.1371/journal.pone.0064961

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