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Resveratrol Has Anabolic Effects on Disc Degeneration in a Rabbit Model
This study was done to evaluate whether injections of resveratrol, a natural compound found in the skin of grapes, had anabolic effects on degenerated intervertebral discs in a rabbit model. Two non-continuous lumbar discs were punctured in rabbits to induce disc degeneration. Four weeks and 6 weeks...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Academy of Medical Sciences
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678014/ https://www.ncbi.nlm.nih.gov/pubmed/23772162 http://dx.doi.org/10.3346/jkms.2013.28.6.939 |
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author | Kwon, Young-Joon |
author_facet | Kwon, Young-Joon |
author_sort | Kwon, Young-Joon |
collection | PubMed |
description | This study was done to evaluate whether injections of resveratrol, a natural compound found in the skin of grapes, had anabolic effects on degenerated intervertebral discs in a rabbit model. Two non-continuous lumbar discs were punctured in rabbits to induce disc degeneration. Four weeks and 6 weeks after puncture, the rabbits were treated by injections with dimethylsulfoxide (DMSO) or resveratrol. At 4, 8, and 16 weeks after initial injection, rabbits were sacrificed and the spine was extracted for magnetic resonance image (MRI), mRNA expression, and histological staining. Resveratrol treatment resulted in stronger signal intensity in T2-weighted images. MRI grade showed significantly lower in the resveratrol group than the DMSO group (P = 0.039). In the resveratrol group, aggrecan gene expression was significantly increased than that in the DMSO group at 16 weeks after injection (P = 0.027). MMP-13 mRNA levels in the resveratrol group were significantly decreased than those in the DMSO group at 8 and 16 weeks (P = 0.006 and P = 0.048, respectively). In hematoxylin and eosin stain, resveratrol-treated discs showed the features of regeneration. Histologic grade revealed improvement in resveratrol-treated discs, compared with DMSO-treated discs (P = 0.024). These anabolic effects on degenerated discs indicate that resveratrol is a promising candidate for treatment of degenerative disc disease. |
format | Online Article Text |
id | pubmed-3678014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-36780142013-06-14 Resveratrol Has Anabolic Effects on Disc Degeneration in a Rabbit Model Kwon, Young-Joon J Korean Med Sci Original Article This study was done to evaluate whether injections of resveratrol, a natural compound found in the skin of grapes, had anabolic effects on degenerated intervertebral discs in a rabbit model. Two non-continuous lumbar discs were punctured in rabbits to induce disc degeneration. Four weeks and 6 weeks after puncture, the rabbits were treated by injections with dimethylsulfoxide (DMSO) or resveratrol. At 4, 8, and 16 weeks after initial injection, rabbits were sacrificed and the spine was extracted for magnetic resonance image (MRI), mRNA expression, and histological staining. Resveratrol treatment resulted in stronger signal intensity in T2-weighted images. MRI grade showed significantly lower in the resveratrol group than the DMSO group (P = 0.039). In the resveratrol group, aggrecan gene expression was significantly increased than that in the DMSO group at 16 weeks after injection (P = 0.027). MMP-13 mRNA levels in the resveratrol group were significantly decreased than those in the DMSO group at 8 and 16 weeks (P = 0.006 and P = 0.048, respectively). In hematoxylin and eosin stain, resveratrol-treated discs showed the features of regeneration. Histologic grade revealed improvement in resveratrol-treated discs, compared with DMSO-treated discs (P = 0.024). These anabolic effects on degenerated discs indicate that resveratrol is a promising candidate for treatment of degenerative disc disease. The Korean Academy of Medical Sciences 2013-06 2013-06-03 /pmc/articles/PMC3678014/ /pubmed/23772162 http://dx.doi.org/10.3346/jkms.2013.28.6.939 Text en © 2013 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kwon, Young-Joon Resveratrol Has Anabolic Effects on Disc Degeneration in a Rabbit Model |
title | Resveratrol Has Anabolic Effects on Disc Degeneration in a Rabbit Model |
title_full | Resveratrol Has Anabolic Effects on Disc Degeneration in a Rabbit Model |
title_fullStr | Resveratrol Has Anabolic Effects on Disc Degeneration in a Rabbit Model |
title_full_unstemmed | Resveratrol Has Anabolic Effects on Disc Degeneration in a Rabbit Model |
title_short | Resveratrol Has Anabolic Effects on Disc Degeneration in a Rabbit Model |
title_sort | resveratrol has anabolic effects on disc degeneration in a rabbit model |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678014/ https://www.ncbi.nlm.nih.gov/pubmed/23772162 http://dx.doi.org/10.3346/jkms.2013.28.6.939 |
work_keys_str_mv | AT kwonyoungjoon resveratrolhasanaboliceffectsondiscdegenerationinarabbitmodel |