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A Case of Acute Pulmonary Embolism Associated with Dysplasminogenemia

The incidence of pulmonary embolism (PE) rises markedly with age, and only a few cases have been reported in younger adults. Thrombophilia has been reported as one of the predisposing factors for PE in younger adults. Here we report an extraordinary case of PE complicated with dysplasminogenemia, a...

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Autores principales: Yoo, Hongseok, Kim, Hee-Jin, Yi, Chin A, Cho, Yoon Young, Joung, Ji Young, Jeong, Hyemin, Jeon, Kyeongman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678018/
https://www.ncbi.nlm.nih.gov/pubmed/23772166
http://dx.doi.org/10.3346/jkms.2013.28.6.959
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author Yoo, Hongseok
Kim, Hee-Jin
Yi, Chin A
Cho, Yoon Young
Joung, Ji Young
Jeong, Hyemin
Jeon, Kyeongman
author_facet Yoo, Hongseok
Kim, Hee-Jin
Yi, Chin A
Cho, Yoon Young
Joung, Ji Young
Jeong, Hyemin
Jeon, Kyeongman
author_sort Yoo, Hongseok
collection PubMed
description The incidence of pulmonary embolism (PE) rises markedly with age, and only a few cases have been reported in younger adults. Thrombophilia has been reported as one of the predisposing factors for PE in younger adults. Here we report an extraordinary case of PE complicated with dysplasminogenemia, a rare genetic disorder resulting in hypercoagulability, in a young male. An 18-yr-old male visited an emergency room in the United States complaining chest discomfort. He was diagnosed as PE with deep vein thrombosis without apparent risk factors. Anticoagulation therapy with warfarin had been initiated and discontinued after 6 months of treatment. After returning to Korea he was tested for thrombophilia which revealed decreased activity of plasminogen and subsequent analysis of PLG gene showed heterozygous Ala620Thr mutation. He was diagnosed with PE complicated with dysplasminogenemia. Life-long anticoagulation therapy was initiated. He is currently under follow-up without clinical events for 2 yr.
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spelling pubmed-36780182013-06-14 A Case of Acute Pulmonary Embolism Associated with Dysplasminogenemia Yoo, Hongseok Kim, Hee-Jin Yi, Chin A Cho, Yoon Young Joung, Ji Young Jeong, Hyemin Jeon, Kyeongman J Korean Med Sci Case Report The incidence of pulmonary embolism (PE) rises markedly with age, and only a few cases have been reported in younger adults. Thrombophilia has been reported as one of the predisposing factors for PE in younger adults. Here we report an extraordinary case of PE complicated with dysplasminogenemia, a rare genetic disorder resulting in hypercoagulability, in a young male. An 18-yr-old male visited an emergency room in the United States complaining chest discomfort. He was diagnosed as PE with deep vein thrombosis without apparent risk factors. Anticoagulation therapy with warfarin had been initiated and discontinued after 6 months of treatment. After returning to Korea he was tested for thrombophilia which revealed decreased activity of plasminogen and subsequent analysis of PLG gene showed heterozygous Ala620Thr mutation. He was diagnosed with PE complicated with dysplasminogenemia. Life-long anticoagulation therapy was initiated. He is currently under follow-up without clinical events for 2 yr. The Korean Academy of Medical Sciences 2013-06 2013-06-03 /pmc/articles/PMC3678018/ /pubmed/23772166 http://dx.doi.org/10.3346/jkms.2013.28.6.959 Text en © 2013 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Yoo, Hongseok
Kim, Hee-Jin
Yi, Chin A
Cho, Yoon Young
Joung, Ji Young
Jeong, Hyemin
Jeon, Kyeongman
A Case of Acute Pulmonary Embolism Associated with Dysplasminogenemia
title A Case of Acute Pulmonary Embolism Associated with Dysplasminogenemia
title_full A Case of Acute Pulmonary Embolism Associated with Dysplasminogenemia
title_fullStr A Case of Acute Pulmonary Embolism Associated with Dysplasminogenemia
title_full_unstemmed A Case of Acute Pulmonary Embolism Associated with Dysplasminogenemia
title_short A Case of Acute Pulmonary Embolism Associated with Dysplasminogenemia
title_sort case of acute pulmonary embolism associated with dysplasminogenemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678018/
https://www.ncbi.nlm.nih.gov/pubmed/23772166
http://dx.doi.org/10.3346/jkms.2013.28.6.959
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