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Co-mutation of histone H2AX S139A with Y142A rescues Y142A-induced ionising radiation sensitivity

Under normal conditions histone H2AX is constitutively phosphorylated on tyrosine (Y) 142 by Williams–Beuren syndrome transcription factor kinase (WSTF). Following DNA double strand breaks (DSB), Y142 is de-phosphorylated and serine (S) 139 is phosphorylated. Here we explored DSB-dependent cross tal...

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Detalles Bibliográficos
Autores principales:	Brown, James A.L., Eykelenboom, John K., Lowndes, Noel F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678120/ https://www.ncbi.nlm.nih.gov/pubmed/23772364 http://dx.doi.org/10.1016/j.fob.2012.09.008

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