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A Wee1 checkpoint inhibits anaphase onset

Cdk1 drives both mitotic entry and the metaphase-to-anaphase transition. Past work has shown that Wee1 inhibition of Cdk1 blocks mitotic entry. Here we show that the budding yeast Wee1 kinase, Swe1, also restrains the metaphase-to-anaphase transition by preventing Cdk1 phosphorylation and activation...

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Detalles Bibliográficos
Autores principales:	Lianga, Noel, Williams, Elizabeth C., Kennedy, Erin K., Doré, Carole, Pilon, Sophie, Girard, Stéphanie L., Deneault, Jean-Sebastien, Rudner, Adam D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678162/ https://www.ncbi.nlm.nih.gov/pubmed/23751495 http://dx.doi.org/10.1083/jcb.201212038

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