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Corneal biomechanics in iatrogenic ectasia and keratoconus: A review of the literature

The Ocular Response Analyzer (ORA) (Reichert Ophthalmic Instruments, Buffalo, NY) allows direct measurement of corneal biomechanical properties. Since its introduction, many studies have sought to elucidate the clinical applications of corneal hysteresis (CH) and corneal resistance factor (CRF). Mor...

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Autores principales: Moshirfar, Majid, Edmonds, Jason N., Behunin, Nicholas L., Christiansen, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678190/
https://www.ncbi.nlm.nih.gov/pubmed/23772119
http://dx.doi.org/10.4103/0974-620X.111895
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author Moshirfar, Majid
Edmonds, Jason N.
Behunin, Nicholas L.
Christiansen, Steven M.
author_facet Moshirfar, Majid
Edmonds, Jason N.
Behunin, Nicholas L.
Christiansen, Steven M.
author_sort Moshirfar, Majid
collection PubMed
description The Ocular Response Analyzer (ORA) (Reichert Ophthalmic Instruments, Buffalo, NY) allows direct measurement of corneal biomechanical properties. Since its introduction, many studies have sought to elucidate the clinical applications of corneal hysteresis (CH) and corneal resistance factor (CRF). More recently, detailed corneal deformation signal waveform analysis (WA) has potentially expanded the diagnostic capabilities of the ORA. In this review, the role of CH, CRF, and WA are examined in keratoconus (KC) and iatrogenic ectasia (IE). The PubMed database was searched electronically for peer-reviewed literature in July 2012 and August 2012 without date restrictions. The search strategy included medical subject heading (MeSH) and natural language terms to retrieve references on corneal biomechanics, CH, CRF, corneal deformation signal WA, IE, and KC. The evidence suggests that while CH and CRF are poor screening tools when used alone, increased sensitivity and specificity of KC and IE screening result when these parameters are combined with tomography and topography. Recent advances in WA are promising, but little is currently understood about its biomechanical and clinical relevance. Future studies should seek to refine the screening protocols for KC and IE as well as define the clinical applicability of WA parameters.
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spelling pubmed-36781902013-06-14 Corneal biomechanics in iatrogenic ectasia and keratoconus: A review of the literature Moshirfar, Majid Edmonds, Jason N. Behunin, Nicholas L. Christiansen, Steven M. Oman J Ophthalmol Review Article The Ocular Response Analyzer (ORA) (Reichert Ophthalmic Instruments, Buffalo, NY) allows direct measurement of corneal biomechanical properties. Since its introduction, many studies have sought to elucidate the clinical applications of corneal hysteresis (CH) and corneal resistance factor (CRF). More recently, detailed corneal deformation signal waveform analysis (WA) has potentially expanded the diagnostic capabilities of the ORA. In this review, the role of CH, CRF, and WA are examined in keratoconus (KC) and iatrogenic ectasia (IE). The PubMed database was searched electronically for peer-reviewed literature in July 2012 and August 2012 without date restrictions. The search strategy included medical subject heading (MeSH) and natural language terms to retrieve references on corneal biomechanics, CH, CRF, corneal deformation signal WA, IE, and KC. The evidence suggests that while CH and CRF are poor screening tools when used alone, increased sensitivity and specificity of KC and IE screening result when these parameters are combined with tomography and topography. Recent advances in WA are promising, but little is currently understood about its biomechanical and clinical relevance. Future studies should seek to refine the screening protocols for KC and IE as well as define the clinical applicability of WA parameters. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3678190/ /pubmed/23772119 http://dx.doi.org/10.4103/0974-620X.111895 Text en Copyright: © Oman Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review Article
Moshirfar, Majid
Edmonds, Jason N.
Behunin, Nicholas L.
Christiansen, Steven M.
Corneal biomechanics in iatrogenic ectasia and keratoconus: A review of the literature
title Corneal biomechanics in iatrogenic ectasia and keratoconus: A review of the literature
title_full Corneal biomechanics in iatrogenic ectasia and keratoconus: A review of the literature
title_fullStr Corneal biomechanics in iatrogenic ectasia and keratoconus: A review of the literature
title_full_unstemmed Corneal biomechanics in iatrogenic ectasia and keratoconus: A review of the literature
title_short Corneal biomechanics in iatrogenic ectasia and keratoconus: A review of the literature
title_sort corneal biomechanics in iatrogenic ectasia and keratoconus: a review of the literature
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678190/
https://www.ncbi.nlm.nih.gov/pubmed/23772119
http://dx.doi.org/10.4103/0974-620X.111895
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