Cargando…
Antiosteoclastic Activity of Milk Thistle Extract after Ovariectomy to Suppress Estrogen Deficiency-Induced Osteoporosis
Bone integrity abnormality and imbalance between bone formation by osteoblasts and bone resorption by osteoclasts are known to result in metabolic bone diseases such as osteoporosis. Silymarin-rich milk thistle extract (MTE) and its component silibinin enhanced alkaline phosphatase activity of osteo...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678416/ https://www.ncbi.nlm.nih.gov/pubmed/23781510 http://dx.doi.org/10.1155/2013/919374 |
_version_ | 1782272846594048000 |
---|---|
author | Kim, Jung-Lye Kim, Yun-Ho Kang, Min-Kyung Gong, Ju-Hyun Han, Seoung-Jun Kang, Young-Hee |
author_facet | Kim, Jung-Lye Kim, Yun-Ho Kang, Min-Kyung Gong, Ju-Hyun Han, Seoung-Jun Kang, Young-Hee |
author_sort | Kim, Jung-Lye |
collection | PubMed |
description | Bone integrity abnormality and imbalance between bone formation by osteoblasts and bone resorption by osteoclasts are known to result in metabolic bone diseases such as osteoporosis. Silymarin-rich milk thistle extract (MTE) and its component silibinin enhanced alkaline phosphatase activity of osteoblasts but reduced tartrate-resistant acid phosphatase (TRAP) activity of osteoclasts. The osteoprotective effects of MTE were comparable to those of estrogenic isoflavone. Low-dose combination of MTE and isoflavone had a pharmacological synergy that may be useful for osteogenic activity. This study attempted to reveal the suppressive effects of MTE on bone loss. C57BL/6 female mice were ovariectomized (OVX) as a model for postmenopausal osteopenia and orally administered 10 mg/kg MTE or silibinin for 8 weeks. The sham-operated mice served as estrogen controls. The treatment of ovariectomized mice with nontoxic MTE and silibinin improved femoral bone mineral density and serum receptor activator of nuclear factor-κB ligand/osteoprotegerin ratio, an index of osteoclastogenic stimulus. In addition, the administration of MTE or silibinin inhibited femoral bone loss induced by ovariectomy and suppressed femoral TRAP activity and cathepsin K induction responsible for osteoclastogenesis and bone resorption. Collectively, oral dosage of MTE containing silibinin in the preclinical setting is effective in preventing estrogen deficiency-induced bone loss. |
format | Online Article Text |
id | pubmed-3678416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36784162013-06-18 Antiosteoclastic Activity of Milk Thistle Extract after Ovariectomy to Suppress Estrogen Deficiency-Induced Osteoporosis Kim, Jung-Lye Kim, Yun-Ho Kang, Min-Kyung Gong, Ju-Hyun Han, Seoung-Jun Kang, Young-Hee Biomed Res Int Research Article Bone integrity abnormality and imbalance between bone formation by osteoblasts and bone resorption by osteoclasts are known to result in metabolic bone diseases such as osteoporosis. Silymarin-rich milk thistle extract (MTE) and its component silibinin enhanced alkaline phosphatase activity of osteoblasts but reduced tartrate-resistant acid phosphatase (TRAP) activity of osteoclasts. The osteoprotective effects of MTE were comparable to those of estrogenic isoflavone. Low-dose combination of MTE and isoflavone had a pharmacological synergy that may be useful for osteogenic activity. This study attempted to reveal the suppressive effects of MTE on bone loss. C57BL/6 female mice were ovariectomized (OVX) as a model for postmenopausal osteopenia and orally administered 10 mg/kg MTE or silibinin for 8 weeks. The sham-operated mice served as estrogen controls. The treatment of ovariectomized mice with nontoxic MTE and silibinin improved femoral bone mineral density and serum receptor activator of nuclear factor-κB ligand/osteoprotegerin ratio, an index of osteoclastogenic stimulus. In addition, the administration of MTE or silibinin inhibited femoral bone loss induced by ovariectomy and suppressed femoral TRAP activity and cathepsin K induction responsible for osteoclastogenesis and bone resorption. Collectively, oral dosage of MTE containing silibinin in the preclinical setting is effective in preventing estrogen deficiency-induced bone loss. Hindawi Publishing Corporation 2013 2013-05-28 /pmc/articles/PMC3678416/ /pubmed/23781510 http://dx.doi.org/10.1155/2013/919374 Text en Copyright © 2013 Jung-Lye Kim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kim, Jung-Lye Kim, Yun-Ho Kang, Min-Kyung Gong, Ju-Hyun Han, Seoung-Jun Kang, Young-Hee Antiosteoclastic Activity of Milk Thistle Extract after Ovariectomy to Suppress Estrogen Deficiency-Induced Osteoporosis |
title | Antiosteoclastic Activity of Milk Thistle Extract after Ovariectomy to Suppress Estrogen Deficiency-Induced Osteoporosis |
title_full | Antiosteoclastic Activity of Milk Thistle Extract after Ovariectomy to Suppress Estrogen Deficiency-Induced Osteoporosis |
title_fullStr | Antiosteoclastic Activity of Milk Thistle Extract after Ovariectomy to Suppress Estrogen Deficiency-Induced Osteoporosis |
title_full_unstemmed | Antiosteoclastic Activity of Milk Thistle Extract after Ovariectomy to Suppress Estrogen Deficiency-Induced Osteoporosis |
title_short | Antiosteoclastic Activity of Milk Thistle Extract after Ovariectomy to Suppress Estrogen Deficiency-Induced Osteoporosis |
title_sort | antiosteoclastic activity of milk thistle extract after ovariectomy to suppress estrogen deficiency-induced osteoporosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678416/ https://www.ncbi.nlm.nih.gov/pubmed/23781510 http://dx.doi.org/10.1155/2013/919374 |
work_keys_str_mv | AT kimjunglye antiosteoclasticactivityofmilkthistleextractafterovariectomytosuppressestrogendeficiencyinducedosteoporosis AT kimyunho antiosteoclasticactivityofmilkthistleextractafterovariectomytosuppressestrogendeficiencyinducedosteoporosis AT kangminkyung antiosteoclasticactivityofmilkthistleextractafterovariectomytosuppressestrogendeficiencyinducedosteoporosis AT gongjuhyun antiosteoclasticactivityofmilkthistleextractafterovariectomytosuppressestrogendeficiencyinducedosteoporosis AT hanseoungjun antiosteoclasticactivityofmilkthistleextractafterovariectomytosuppressestrogendeficiencyinducedosteoporosis AT kangyounghee antiosteoclasticactivityofmilkthistleextractafterovariectomytosuppressestrogendeficiencyinducedosteoporosis |