Cargando…
The Link between Ankylosing Spondylitis, Crohn's Disease, Klebsiella, and Starch Consumption
Both ankylosing spondylitis (AS) and Crohn's disease (CD) are chronic and potentially disabling interrelated conditions, which have been included under the group of spondyloarthropathies. The results of a large number of studies support the idea that an enteropathic pathogen, Klebsiella pneumon...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678459/ https://www.ncbi.nlm.nih.gov/pubmed/23781254 http://dx.doi.org/10.1155/2013/872632 |
_version_ | 1782272856624726016 |
---|---|
author | Rashid, Taha Wilson, Clyde Ebringer, Alan |
author_facet | Rashid, Taha Wilson, Clyde Ebringer, Alan |
author_sort | Rashid, Taha |
collection | PubMed |
description | Both ankylosing spondylitis (AS) and Crohn's disease (CD) are chronic and potentially disabling interrelated conditions, which have been included under the group of spondyloarthropathies. The results of a large number of studies support the idea that an enteropathic pathogen, Klebsiella pneumoniae, is the most likely triggering factor involved in the initiation and development of these diseases. Increased starch consumptions by genetically susceptible individuals such as those possessing HLA-B27 allelotypes could trigger the disease in both AS and CD by enhancing the growth and perpetuation of the Klebsiella microbes in the bowel. Exposure to increased levels of these microbes will lead to the production of elevated levels of anti-Klebsiella antibodies as well as autoantibodies against cross-reactive self-antigens with resultant pathological lesions in the bowel and joints. Hence, a decrease of starch-containing products in the daily dietary intake could have a beneficial therapeutic effect on the disease especially when used in conjunction with the currently available medical therapies in the treatment of patients with AS and CD. |
format | Online Article Text |
id | pubmed-3678459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36784592013-06-18 The Link between Ankylosing Spondylitis, Crohn's Disease, Klebsiella, and Starch Consumption Rashid, Taha Wilson, Clyde Ebringer, Alan Clin Dev Immunol Review Article Both ankylosing spondylitis (AS) and Crohn's disease (CD) are chronic and potentially disabling interrelated conditions, which have been included under the group of spondyloarthropathies. The results of a large number of studies support the idea that an enteropathic pathogen, Klebsiella pneumoniae, is the most likely triggering factor involved in the initiation and development of these diseases. Increased starch consumptions by genetically susceptible individuals such as those possessing HLA-B27 allelotypes could trigger the disease in both AS and CD by enhancing the growth and perpetuation of the Klebsiella microbes in the bowel. Exposure to increased levels of these microbes will lead to the production of elevated levels of anti-Klebsiella antibodies as well as autoantibodies against cross-reactive self-antigens with resultant pathological lesions in the bowel and joints. Hence, a decrease of starch-containing products in the daily dietary intake could have a beneficial therapeutic effect on the disease especially when used in conjunction with the currently available medical therapies in the treatment of patients with AS and CD. Hindawi Publishing Corporation 2013 2013-05-27 /pmc/articles/PMC3678459/ /pubmed/23781254 http://dx.doi.org/10.1155/2013/872632 Text en Copyright © 2013 Taha Rashid et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Rashid, Taha Wilson, Clyde Ebringer, Alan The Link between Ankylosing Spondylitis, Crohn's Disease, Klebsiella, and Starch Consumption |
title | The Link between Ankylosing Spondylitis, Crohn's Disease, Klebsiella, and Starch Consumption |
title_full | The Link between Ankylosing Spondylitis, Crohn's Disease, Klebsiella, and Starch Consumption |
title_fullStr | The Link between Ankylosing Spondylitis, Crohn's Disease, Klebsiella, and Starch Consumption |
title_full_unstemmed | The Link between Ankylosing Spondylitis, Crohn's Disease, Klebsiella, and Starch Consumption |
title_short | The Link between Ankylosing Spondylitis, Crohn's Disease, Klebsiella, and Starch Consumption |
title_sort | link between ankylosing spondylitis, crohn's disease, klebsiella, and starch consumption |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678459/ https://www.ncbi.nlm.nih.gov/pubmed/23781254 http://dx.doi.org/10.1155/2013/872632 |
work_keys_str_mv | AT rashidtaha thelinkbetweenankylosingspondylitiscrohnsdiseaseklebsiellaandstarchconsumption AT wilsonclyde thelinkbetweenankylosingspondylitiscrohnsdiseaseklebsiellaandstarchconsumption AT ebringeralan thelinkbetweenankylosingspondylitiscrohnsdiseaseklebsiellaandstarchconsumption AT rashidtaha linkbetweenankylosingspondylitiscrohnsdiseaseklebsiellaandstarchconsumption AT wilsonclyde linkbetweenankylosingspondylitiscrohnsdiseaseklebsiellaandstarchconsumption AT ebringeralan linkbetweenankylosingspondylitiscrohnsdiseaseklebsiellaandstarchconsumption |