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Mate choice for genetic compatibility in the house mouse

In house mice, genetic compatibility is influenced by the t haplotype, a driving selfish genetic element with a recessive lethal allele, imposing fundamental costs on mate choice decisions. Here, we evaluate the cost of genetic incompatibility and its implication for mate choice in a wild house mice...

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Autores principales: Lindholm, Anna K, Musolf, Kerstin, Weidt, Andrea, König, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678478/
https://www.ncbi.nlm.nih.gov/pubmed/23762510
http://dx.doi.org/10.1002/ece3.534
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author Lindholm, Anna K
Musolf, Kerstin
Weidt, Andrea
König, Barbara
author_facet Lindholm, Anna K
Musolf, Kerstin
Weidt, Andrea
König, Barbara
author_sort Lindholm, Anna K
collection PubMed
description In house mice, genetic compatibility is influenced by the t haplotype, a driving selfish genetic element with a recessive lethal allele, imposing fundamental costs on mate choice decisions. Here, we evaluate the cost of genetic incompatibility and its implication for mate choice in a wild house mice population. In laboratory reared mice, we detected no fertility (number of embryos) or fecundity (ability to conceive) costs of the t, and yet we found a high cost of genetic incompatibility: heterozygote crosses produced 40% smaller birth litter sizes because of prenatal mortality. Surprisingly, transmission of t in crosses using +/t males was influenced by female genotype, consistent with postcopulatory female choice for + sperm in +/t females. Analysis of paternity patterns in a wild population of house mice showed that +/t females were more likely than +/+ females to have offspring sired by +/+ males, and unlike +/+ females, paternity of their offspring was not influenced by +/t male frequency, further supporting mate choice for genetic compatibility. As the major histocompatibility complex (MHC) is physically linked to the t, we investigated whether females could potentially use variation at the MHC to identify male genotype at the sperm or individual level. A unique MHC haplotype is linked to the t haplotype. This MHC haplotype could allow the recognition of t and enable pre- and postcopulatory mate choice for genetic compatibility. Alternatively, the MHC itself could be the target of mate choice for genetic compatibility. We predict that mate choice for genetic compatibility will be difficult to find in many systems, as only weak fertilization biases were found despite an exceptionally high cost of genetic incompatibility.
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spelling pubmed-36784782013-06-12 Mate choice for genetic compatibility in the house mouse Lindholm, Anna K Musolf, Kerstin Weidt, Andrea König, Barbara Ecol Evol Original Research In house mice, genetic compatibility is influenced by the t haplotype, a driving selfish genetic element with a recessive lethal allele, imposing fundamental costs on mate choice decisions. Here, we evaluate the cost of genetic incompatibility and its implication for mate choice in a wild house mice population. In laboratory reared mice, we detected no fertility (number of embryos) or fecundity (ability to conceive) costs of the t, and yet we found a high cost of genetic incompatibility: heterozygote crosses produced 40% smaller birth litter sizes because of prenatal mortality. Surprisingly, transmission of t in crosses using +/t males was influenced by female genotype, consistent with postcopulatory female choice for + sperm in +/t females. Analysis of paternity patterns in a wild population of house mice showed that +/t females were more likely than +/+ females to have offspring sired by +/+ males, and unlike +/+ females, paternity of their offspring was not influenced by +/t male frequency, further supporting mate choice for genetic compatibility. As the major histocompatibility complex (MHC) is physically linked to the t, we investigated whether females could potentially use variation at the MHC to identify male genotype at the sperm or individual level. A unique MHC haplotype is linked to the t haplotype. This MHC haplotype could allow the recognition of t and enable pre- and postcopulatory mate choice for genetic compatibility. Alternatively, the MHC itself could be the target of mate choice for genetic compatibility. We predict that mate choice for genetic compatibility will be difficult to find in many systems, as only weak fertilization biases were found despite an exceptionally high cost of genetic incompatibility. Blackwell Publishing Ltd 2013-05 2013-03-20 /pmc/articles/PMC3678478/ /pubmed/23762510 http://dx.doi.org/10.1002/ece3.534 Text en © 2013 Published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Original Research
Lindholm, Anna K
Musolf, Kerstin
Weidt, Andrea
König, Barbara
Mate choice for genetic compatibility in the house mouse
title Mate choice for genetic compatibility in the house mouse
title_full Mate choice for genetic compatibility in the house mouse
title_fullStr Mate choice for genetic compatibility in the house mouse
title_full_unstemmed Mate choice for genetic compatibility in the house mouse
title_short Mate choice for genetic compatibility in the house mouse
title_sort mate choice for genetic compatibility in the house mouse
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678478/
https://www.ncbi.nlm.nih.gov/pubmed/23762510
http://dx.doi.org/10.1002/ece3.534
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