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The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging
The haptoglobin- (Hp-) CD163-heme oxygenase-1 (HO-1) pathway is an efficient captor-receptor-enzyme system to circumvent the hemoglobin (Hb)/heme-induced toxicity during physiological and pathological hemolyses. In this pathway, Hb tightly binds to Hp leading to CD163-mediated uptake of the complex...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678498/ https://www.ncbi.nlm.nih.gov/pubmed/23781295 http://dx.doi.org/10.1155/2013/523652 |
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author | Thomsen, Jens Haugbølle Etzerodt, Anders Svendsen, Pia Moestrup, Søren K. |
author_facet | Thomsen, Jens Haugbølle Etzerodt, Anders Svendsen, Pia Moestrup, Søren K. |
author_sort | Thomsen, Jens Haugbølle |
collection | PubMed |
description | The haptoglobin- (Hp-) CD163-heme oxygenase-1 (HO-1) pathway is an efficient captor-receptor-enzyme system to circumvent the hemoglobin (Hb)/heme-induced toxicity during physiological and pathological hemolyses. In this pathway, Hb tightly binds to Hp leading to CD163-mediated uptake of the complex in macrophages followed by lysosomal Hp-Hb breakdown and HO-1-catalyzed conversion of heme into the metabolites carbon monoxide (CO), biliverdin, and iron. The plasma concentration of Hp is a limiting factor as evident during accelerated hemolysis, where the Hp depletion may cause serious Hb-induced toxicity and put pressure on backup protecting systems such as the hemopexin-CD91-HO pathway. The Hp-CD163-HO-1 pathway proteins are regulated by the acute phase mediator interleukin-6 (IL-6), but other regulatory factors indicate that this upregulation is a counteracting anti-inflammatory response during inflammation. The heme metabolites including bilirubin converted from biliverdin have overall an anti-inflammatory effect and thus reinforce the anti-inflammatory efficacy of the Hp-CD163-HO-1 pathway. Future studies of animal models of inflammation should further define the importance of the pathway in the anti-inflammatory response. |
format | Online Article Text |
id | pubmed-3678498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36784982013-06-18 The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging Thomsen, Jens Haugbølle Etzerodt, Anders Svendsen, Pia Moestrup, Søren K. Oxid Med Cell Longev Review Article The haptoglobin- (Hp-) CD163-heme oxygenase-1 (HO-1) pathway is an efficient captor-receptor-enzyme system to circumvent the hemoglobin (Hb)/heme-induced toxicity during physiological and pathological hemolyses. In this pathway, Hb tightly binds to Hp leading to CD163-mediated uptake of the complex in macrophages followed by lysosomal Hp-Hb breakdown and HO-1-catalyzed conversion of heme into the metabolites carbon monoxide (CO), biliverdin, and iron. The plasma concentration of Hp is a limiting factor as evident during accelerated hemolysis, where the Hp depletion may cause serious Hb-induced toxicity and put pressure on backup protecting systems such as the hemopexin-CD91-HO pathway. The Hp-CD163-HO-1 pathway proteins are regulated by the acute phase mediator interleukin-6 (IL-6), but other regulatory factors indicate that this upregulation is a counteracting anti-inflammatory response during inflammation. The heme metabolites including bilirubin converted from biliverdin have overall an anti-inflammatory effect and thus reinforce the anti-inflammatory efficacy of the Hp-CD163-HO-1 pathway. Future studies of animal models of inflammation should further define the importance of the pathway in the anti-inflammatory response. Hindawi Publishing Corporation 2013 2013-05-27 /pmc/articles/PMC3678498/ /pubmed/23781295 http://dx.doi.org/10.1155/2013/523652 Text en Copyright © 2013 Jens Haugbølle Thomsen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Thomsen, Jens Haugbølle Etzerodt, Anders Svendsen, Pia Moestrup, Søren K. The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging |
title | The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging |
title_full | The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging |
title_fullStr | The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging |
title_full_unstemmed | The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging |
title_short | The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging |
title_sort | haptoglobin-cd163-heme oxygenase-1 pathway for hemoglobin scavenging |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678498/ https://www.ncbi.nlm.nih.gov/pubmed/23781295 http://dx.doi.org/10.1155/2013/523652 |
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