A versatile and efficient approach for the synthesis of chiral 1,3-nitroamines and 1,3-diamines via conjugate addition to new (S,E)-γ-aminated nitroalkenes derived from L-α-amino acids

New chiral (S,E)-γ-N,N-dibenzylated nitroalkenes 2a–c were synthesized from natural L-(α)-amino acids in five steps with overall yields of 68–88%. The conjugate addition of hydride, methoxide, nitronate and azide nucleophiles to 2a–c led to the corresponding chiral 1,3-nitroamines in 74–90% yield. T...

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Detalles Bibliográficos
Autores principales: Pereira, Vera Lúcia Patrocinio, Moura, André Luiz da Silva, Vieira, Daniel Pais Pires, de Carvalho, Leandro Lara, Torres, Eliz Regina Bueno, Costa, Jeronimo da Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678503/
https://www.ncbi.nlm.nih.gov/pubmed/23766797
http://dx.doi.org/10.3762/bjoc.9.95

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