Simple synthesis of pyrrolo[3,2-e]indole-1-carbonitriles

Alkylation of 5-nitroindol-4-ylacetonitriles with ethyl chloroacetate, α-halomethyl ketones, and chloroacetonitrile followed by a treatment of the products with chlorotrimethylsilane in the presence of DBU gives 1-cyanopyrrolo[3,2-e]indoles substituted in position 2 with electron-withdrawing groups....

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Autores principales: Trawczyński, Adam, Bujok, Robert, Wróbel, Zbigniew, Wojciechowski, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678543/
https://www.ncbi.nlm.nih.gov/pubmed/23766809
http://dx.doi.org/10.3762/bjoc.9.107
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author Trawczyński, Adam
Bujok, Robert
Wróbel, Zbigniew
Wojciechowski, Krzysztof
author_facet Trawczyński, Adam
Bujok, Robert
Wróbel, Zbigniew
Wojciechowski, Krzysztof
author_sort Trawczyński, Adam
collection PubMed
description Alkylation of 5-nitroindol-4-ylacetonitriles with ethyl chloroacetate, α-halomethyl ketones, and chloroacetonitrile followed by a treatment of the products with chlorotrimethylsilane in the presence of DBU gives 1-cyanopyrrolo[3,2-e]indoles substituted in position 2 with electron-withdrawing groups.
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spelling pubmed-36785432013-06-13 Simple synthesis of pyrrolo[3,2-e]indole-1-carbonitriles Trawczyński, Adam Bujok, Robert Wróbel, Zbigniew Wojciechowski, Krzysztof Beilstein J Org Chem Full Research Paper Alkylation of 5-nitroindol-4-ylacetonitriles with ethyl chloroacetate, α-halomethyl ketones, and chloroacetonitrile followed by a treatment of the products with chlorotrimethylsilane in the presence of DBU gives 1-cyanopyrrolo[3,2-e]indoles substituted in position 2 with electron-withdrawing groups. Beilstein-Institut 2013-05-15 /pmc/articles/PMC3678543/ /pubmed/23766809 http://dx.doi.org/10.3762/bjoc.9.107 Text en Copyright © 2013, Trawczyński et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Trawczyński, Adam
Bujok, Robert
Wróbel, Zbigniew
Wojciechowski, Krzysztof
Simple synthesis of pyrrolo[3,2-e]indole-1-carbonitriles
title Simple synthesis of pyrrolo[3,2-e]indole-1-carbonitriles
title_full Simple synthesis of pyrrolo[3,2-e]indole-1-carbonitriles
title_fullStr Simple synthesis of pyrrolo[3,2-e]indole-1-carbonitriles
title_full_unstemmed Simple synthesis of pyrrolo[3,2-e]indole-1-carbonitriles
title_short Simple synthesis of pyrrolo[3,2-e]indole-1-carbonitriles
title_sort simple synthesis of pyrrolo[3,2-e]indole-1-carbonitriles
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678543/
https://www.ncbi.nlm.nih.gov/pubmed/23766809
http://dx.doi.org/10.3762/bjoc.9.107
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