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Influence of genetic and environmental factors in peripheral arterial disease natural history: Analysis from six years follow up

BACKGROUND: Peripheral arterial disease (PAD) is a disease affecting million of patients worldwide. Though traditional cardiovascular risk factors have been associated with the development of PAD, the possible existence of an inherited genetic predisposition to PAD has been investigated in few famil...

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Autores principales: Archetti, S, Martini, M, Botteri, E, Di Lorenzo, D, Cervi, E, Bonardelli, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678691/
https://www.ncbi.nlm.nih.gov/pubmed/23776824
http://dx.doi.org/10.4103/2229-516X.106354
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author Archetti, S
Martini, M
Botteri, E
Di Lorenzo, D
Cervi, E
Bonardelli, S
author_facet Archetti, S
Martini, M
Botteri, E
Di Lorenzo, D
Cervi, E
Bonardelli, S
author_sort Archetti, S
collection PubMed
description BACKGROUND: Peripheral arterial disease (PAD) is a disease affecting million of patients worldwide. Though traditional cardiovascular risk factors have been associated with the development of PAD, the possible existence of an inherited genetic predisposition to PAD has been investigated in few familial aggregation studies. A link between genetics and PAD may open new avenues for the prevention of this morbid and mortal disorder. AIM: The aim of this study is to investigate a possible role of some genetic determinant involving into coagulation and homocysteine metabolism in the progression of PAD. MATERIALS AND METHODS: We follow one-hundred patients affected by PAD for six years. We evaluated Ankle-Brachial Index (ABI) two times; first at the time of recruitment and then after six years, in order to assess the progression of disease. Genotypes for the genes of Factor V Leiden, Prothrombin or Factor II G20210A, Cystathionine Beta-Synthase 844ins68bp and Methylenetetrahydrofolate Reductase C677T was ascertained after taking blood samples. Chi-square test was performed to determinate the possible correlation of these genes and the most common environmental factors in the progression of PAD. RESULTS: Genetic disorders resulting in high level of homocysteina or thrombophilic phenotype are not so frequent. None among the genetic factors we considered were correlated with PAD. CONCLUSION: PAD is a chronic disease whose course can be slowed down especially with the control of environmental risk factors. Genetic analyses are not useful to determine the disease progression or its tendency to remain stable.
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spelling pubmed-36786912013-06-17 Influence of genetic and environmental factors in peripheral arterial disease natural history: Analysis from six years follow up Archetti, S Martini, M Botteri, E Di Lorenzo, D Cervi, E Bonardelli, S Int J Appl Basic Med Res Original Article BACKGROUND: Peripheral arterial disease (PAD) is a disease affecting million of patients worldwide. Though traditional cardiovascular risk factors have been associated with the development of PAD, the possible existence of an inherited genetic predisposition to PAD has been investigated in few familial aggregation studies. A link between genetics and PAD may open new avenues for the prevention of this morbid and mortal disorder. AIM: The aim of this study is to investigate a possible role of some genetic determinant involving into coagulation and homocysteine metabolism in the progression of PAD. MATERIALS AND METHODS: We follow one-hundred patients affected by PAD for six years. We evaluated Ankle-Brachial Index (ABI) two times; first at the time of recruitment and then after six years, in order to assess the progression of disease. Genotypes for the genes of Factor V Leiden, Prothrombin or Factor II G20210A, Cystathionine Beta-Synthase 844ins68bp and Methylenetetrahydrofolate Reductase C677T was ascertained after taking blood samples. Chi-square test was performed to determinate the possible correlation of these genes and the most common environmental factors in the progression of PAD. RESULTS: Genetic disorders resulting in high level of homocysteina or thrombophilic phenotype are not so frequent. None among the genetic factors we considered were correlated with PAD. CONCLUSION: PAD is a chronic disease whose course can be slowed down especially with the control of environmental risk factors. Genetic analyses are not useful to determine the disease progression or its tendency to remain stable. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3678691/ /pubmed/23776824 http://dx.doi.org/10.4103/2229-516X.106354 Text en Copyright: © International Journal of Applied and Basic Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Archetti, S
Martini, M
Botteri, E
Di Lorenzo, D
Cervi, E
Bonardelli, S
Influence of genetic and environmental factors in peripheral arterial disease natural history: Analysis from six years follow up
title Influence of genetic and environmental factors in peripheral arterial disease natural history: Analysis from six years follow up
title_full Influence of genetic and environmental factors in peripheral arterial disease natural history: Analysis from six years follow up
title_fullStr Influence of genetic and environmental factors in peripheral arterial disease natural history: Analysis from six years follow up
title_full_unstemmed Influence of genetic and environmental factors in peripheral arterial disease natural history: Analysis from six years follow up
title_short Influence of genetic and environmental factors in peripheral arterial disease natural history: Analysis from six years follow up
title_sort influence of genetic and environmental factors in peripheral arterial disease natural history: analysis from six years follow up
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678691/
https://www.ncbi.nlm.nih.gov/pubmed/23776824
http://dx.doi.org/10.4103/2229-516X.106354
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