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Ki-67 and CD100 immunohistochemical expression is associated with local recurrence and poor prognosis in soft tissue sarcomas, respectively

Soft tissue sarcomas (STSs) are a heterogeneous group of mesenchymal tumors of >50 subtypes. However, STSs represent <1% of types of cancer. Despite this low frequency, the disease is aggressive and treatment, when possible, is based on traditional chemotherapies. A number of cases of resistan...

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Autores principales: CAMPOS, MARCELO, DE CAMPOS, SILVANA GISELE PEGORIN, RIBEIRO, GUILHERME GOMES, EGUCHI, FLÁVIA COLTRI, SILVA, SANDRA REGINA MORINI DA, DE OLIVEIRA, CLEYTON ZANARDO, DA COSTA, ALLINI MAFRA, CURCELLI, EMÍLIO CARLOS, NUNES, MARCOS CEITA, PENNA, VALTER, LONGATTO-FILHO, ADHEMAR
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678859/
https://www.ncbi.nlm.nih.gov/pubmed/23759874
http://dx.doi.org/10.3892/ol.2013.1226
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author CAMPOS, MARCELO
DE CAMPOS, SILVANA GISELE PEGORIN
RIBEIRO, GUILHERME GOMES
EGUCHI, FLÁVIA COLTRI
SILVA, SANDRA REGINA MORINI DA
DE OLIVEIRA, CLEYTON ZANARDO
DA COSTA, ALLINI MAFRA
CURCELLI, EMÍLIO CARLOS
NUNES, MARCOS CEITA
PENNA, VALTER
LONGATTO-FILHO, ADHEMAR
author_facet CAMPOS, MARCELO
DE CAMPOS, SILVANA GISELE PEGORIN
RIBEIRO, GUILHERME GOMES
EGUCHI, FLÁVIA COLTRI
SILVA, SANDRA REGINA MORINI DA
DE OLIVEIRA, CLEYTON ZANARDO
DA COSTA, ALLINI MAFRA
CURCELLI, EMÍLIO CARLOS
NUNES, MARCOS CEITA
PENNA, VALTER
LONGATTO-FILHO, ADHEMAR
author_sort CAMPOS, MARCELO
collection PubMed
description Soft tissue sarcomas (STSs) are a heterogeneous group of mesenchymal tumors of >50 subtypes. However, STSs represent <1% of types of cancer. Despite this low frequency, the disease is aggressive and treatment, when possible, is based on traditional chemotherapies. A number of cases of resistance to adjuvant therapies have been reported. Metastases are commonly identified in STS patients during diagnosis and the development of effective clinical parameters is crucial for correct management of the disease. The use of biological markers in cancer is a useful tool to determine patient prognosis. Ki-67 is a protein marker for proliferation of somatic cells and is widely used in prognostic studies of various types of tumor, including STSs. Cluster of differentiation 100 (CD100) is a member of the semaphorin family. The family was initially described as axon guidance molecules important for angiogenesis, organogenesis, apoptosis and neoplasia. CD100 was previously utilized as a prognostic factor in tumors and also in STSs. In the present study, protein expression of Ki-67 and CD100 was analyzed by immunohistochemistry in samples of STS patients of the Barretos Cancer Hospital (Barretos, Brazil) to establish prognostic criteria of the disease. Results demonstrate a correlation between CD100 expression and poor prognosis, consistent with a previous study. Moreover, the expression of Ki-67 was identified to correlate with presence of local or locoregional recurrence. To the best of our knowledge, no large casuistic study has revealed this correlation between Ki-67 and local recurrence in STSs. The use of Ki-67 and CD100 as markers in clinical pathological analysis may be suitable as a prognostic criterion in disease progression.
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spelling pubmed-36788592013-06-11 Ki-67 and CD100 immunohistochemical expression is associated with local recurrence and poor prognosis in soft tissue sarcomas, respectively CAMPOS, MARCELO DE CAMPOS, SILVANA GISELE PEGORIN RIBEIRO, GUILHERME GOMES EGUCHI, FLÁVIA COLTRI SILVA, SANDRA REGINA MORINI DA DE OLIVEIRA, CLEYTON ZANARDO DA COSTA, ALLINI MAFRA CURCELLI, EMÍLIO CARLOS NUNES, MARCOS CEITA PENNA, VALTER LONGATTO-FILHO, ADHEMAR Oncol Lett Articles Soft tissue sarcomas (STSs) are a heterogeneous group of mesenchymal tumors of >50 subtypes. However, STSs represent <1% of types of cancer. Despite this low frequency, the disease is aggressive and treatment, when possible, is based on traditional chemotherapies. A number of cases of resistance to adjuvant therapies have been reported. Metastases are commonly identified in STS patients during diagnosis and the development of effective clinical parameters is crucial for correct management of the disease. The use of biological markers in cancer is a useful tool to determine patient prognosis. Ki-67 is a protein marker for proliferation of somatic cells and is widely used in prognostic studies of various types of tumor, including STSs. Cluster of differentiation 100 (CD100) is a member of the semaphorin family. The family was initially described as axon guidance molecules important for angiogenesis, organogenesis, apoptosis and neoplasia. CD100 was previously utilized as a prognostic factor in tumors and also in STSs. In the present study, protein expression of Ki-67 and CD100 was analyzed by immunohistochemistry in samples of STS patients of the Barretos Cancer Hospital (Barretos, Brazil) to establish prognostic criteria of the disease. Results demonstrate a correlation between CD100 expression and poor prognosis, consistent with a previous study. Moreover, the expression of Ki-67 was identified to correlate with presence of local or locoregional recurrence. To the best of our knowledge, no large casuistic study has revealed this correlation between Ki-67 and local recurrence in STSs. The use of Ki-67 and CD100 as markers in clinical pathological analysis may be suitable as a prognostic criterion in disease progression. D.A. Spandidos 2013-05 2013-03-05 /pmc/articles/PMC3678859/ /pubmed/23759874 http://dx.doi.org/10.3892/ol.2013.1226 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
CAMPOS, MARCELO
DE CAMPOS, SILVANA GISELE PEGORIN
RIBEIRO, GUILHERME GOMES
EGUCHI, FLÁVIA COLTRI
SILVA, SANDRA REGINA MORINI DA
DE OLIVEIRA, CLEYTON ZANARDO
DA COSTA, ALLINI MAFRA
CURCELLI, EMÍLIO CARLOS
NUNES, MARCOS CEITA
PENNA, VALTER
LONGATTO-FILHO, ADHEMAR
Ki-67 and CD100 immunohistochemical expression is associated with local recurrence and poor prognosis in soft tissue sarcomas, respectively
title Ki-67 and CD100 immunohistochemical expression is associated with local recurrence and poor prognosis in soft tissue sarcomas, respectively
title_full Ki-67 and CD100 immunohistochemical expression is associated with local recurrence and poor prognosis in soft tissue sarcomas, respectively
title_fullStr Ki-67 and CD100 immunohistochemical expression is associated with local recurrence and poor prognosis in soft tissue sarcomas, respectively
title_full_unstemmed Ki-67 and CD100 immunohistochemical expression is associated with local recurrence and poor prognosis in soft tissue sarcomas, respectively
title_short Ki-67 and CD100 immunohistochemical expression is associated with local recurrence and poor prognosis in soft tissue sarcomas, respectively
title_sort ki-67 and cd100 immunohistochemical expression is associated with local recurrence and poor prognosis in soft tissue sarcomas, respectively
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678859/
https://www.ncbi.nlm.nih.gov/pubmed/23759874
http://dx.doi.org/10.3892/ol.2013.1226
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