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Gemcitabine plus oxaliplatin for the treatment of leptomeningeal metastases of non-small cell lung cancer: A case report and review of the literature

A 62-year-old male presented with stage IV lung adenocarcinoma with leptomeningeal metastases (LM). Gemcitabine (1000 mg/m(2) i.v.) was administered on days 1 and 8 while oxaliplatin (100/m(2) i.v.) was administered on day 1 and repeated for 4 cycles every 3 weeks. Computerized tomography (CT) and c...

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Autores principales: BAI, CHONG, SHI, HUI, LIU, DAN, ZHU, TIANYI, HU, ZHENLI, LI, QIANG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678890/
https://www.ncbi.nlm.nih.gov/pubmed/23760544
http://dx.doi.org/10.3892/ol.2013.1263
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author BAI, CHONG
SHI, HUI
LIU, DAN
ZHU, TIANYI
HU, ZHENLI
LI, QIANG
author_facet BAI, CHONG
SHI, HUI
LIU, DAN
ZHU, TIANYI
HU, ZHENLI
LI, QIANG
author_sort BAI, CHONG
collection PubMed
description A 62-year-old male presented with stage IV lung adenocarcinoma with leptomeningeal metastases (LM). Gemcitabine (1000 mg/m(2) i.v.) was administered on days 1 and 8 while oxaliplatin (100/m(2) i.v.) was administered on day 1 and repeated for 4 cycles every 3 weeks. Computerized tomography (CT) and cerebrospinal fluid (CSF) were used to evaluate the response of the LM and the primary tumor to drug therapy. Following the administration of chemotherapy, headaches were observed to be notably reduced 6 days later and absent after 14 days. The symptoms of coughing and chest pain were alleviated. Subsequent to 4 cycles of treatment, the patient had a partial response (PR) and the CSF pressure was normal. Analysis of the CSF revealed that it was colorless, positive for protein, had a total cell number of 0/l and contained no cancer cells. However, the primary lung tumor progressed for 1 year. This may suggest that first-line therapies, including the use of gemcitabine and oxalipaltin, may be appropriate for the treatment of non-small cell lung carcinoma (NSCLC) with LM involvement.
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spelling pubmed-36788902013-06-11 Gemcitabine plus oxaliplatin for the treatment of leptomeningeal metastases of non-small cell lung cancer: A case report and review of the literature BAI, CHONG SHI, HUI LIU, DAN ZHU, TIANYI HU, ZHENLI LI, QIANG Oncol Lett Articles A 62-year-old male presented with stage IV lung adenocarcinoma with leptomeningeal metastases (LM). Gemcitabine (1000 mg/m(2) i.v.) was administered on days 1 and 8 while oxaliplatin (100/m(2) i.v.) was administered on day 1 and repeated for 4 cycles every 3 weeks. Computerized tomography (CT) and cerebrospinal fluid (CSF) were used to evaluate the response of the LM and the primary tumor to drug therapy. Following the administration of chemotherapy, headaches were observed to be notably reduced 6 days later and absent after 14 days. The symptoms of coughing and chest pain were alleviated. Subsequent to 4 cycles of treatment, the patient had a partial response (PR) and the CSF pressure was normal. Analysis of the CSF revealed that it was colorless, positive for protein, had a total cell number of 0/l and contained no cancer cells. However, the primary lung tumor progressed for 1 year. This may suggest that first-line therapies, including the use of gemcitabine and oxalipaltin, may be appropriate for the treatment of non-small cell lung carcinoma (NSCLC) with LM involvement. D.A. Spandidos 2013-05 2013-03-19 /pmc/articles/PMC3678890/ /pubmed/23760544 http://dx.doi.org/10.3892/ol.2013.1263 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
BAI, CHONG
SHI, HUI
LIU, DAN
ZHU, TIANYI
HU, ZHENLI
LI, QIANG
Gemcitabine plus oxaliplatin for the treatment of leptomeningeal metastases of non-small cell lung cancer: A case report and review of the literature
title Gemcitabine plus oxaliplatin for the treatment of leptomeningeal metastases of non-small cell lung cancer: A case report and review of the literature
title_full Gemcitabine plus oxaliplatin for the treatment of leptomeningeal metastases of non-small cell lung cancer: A case report and review of the literature
title_fullStr Gemcitabine plus oxaliplatin for the treatment of leptomeningeal metastases of non-small cell lung cancer: A case report and review of the literature
title_full_unstemmed Gemcitabine plus oxaliplatin for the treatment of leptomeningeal metastases of non-small cell lung cancer: A case report and review of the literature
title_short Gemcitabine plus oxaliplatin for the treatment of leptomeningeal metastases of non-small cell lung cancer: A case report and review of the literature
title_sort gemcitabine plus oxaliplatin for the treatment of leptomeningeal metastases of non-small cell lung cancer: a case report and review of the literature
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678890/
https://www.ncbi.nlm.nih.gov/pubmed/23760544
http://dx.doi.org/10.3892/ol.2013.1263
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