A Structural Basis for IκB Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation

Activation of the IκB kinase (IKK) is central to NF-κB signaling. However, the precise activation mechanism by which catalytic IKK subunits gain the ability to induce NF-κB transcriptional activity is not well understood. Here we report a 4 Å x-ray crystal structure of human IKK2 (hIKK2) in its cata...

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Detalles Bibliográficos
Autores principales: Polley, Smarajit, Huang, De-Bin, Hauenstein, Arthur V., Fusco, Amanda J., Zhong, Xiangyang, Vu, Don, Schröfelbauer, Bärbel, Kim, Youngchang, Hoffmann, Alexander, Verma, Inder M., Ghosh, Gourisankar, Huxford, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678999/
https://www.ncbi.nlm.nih.gov/pubmed/23776406
http://dx.doi.org/10.1371/journal.pbio.1001581

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