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Vaccination with Recombinant Mycobacterium tuberculosis PknD Attenuates Bacterial Dissemination to the Brain in Guinea Pigs

BACKGROUND: We have previously identified Mycobacterium tuberculosis PknD to be an important virulence factor required for the pathogenesis of central nervous system (CNS) tuberculosis (TB). Specifically, PknD mediates bacillary invasion of the blood-brain barrier, which can be neutralized by specif...

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Detalles Bibliográficos
Autores principales:	Skerry, Ciaran, Pokkali, Supriya, Pinn, Michael, Be, Nicholas A., Harper, Jamie, Karakousis, Petros C., Jain, Sanjay K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679071/ https://www.ncbi.nlm.nih.gov/pubmed/23776655 http://dx.doi.org/10.1371/journal.pone.0066310

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