Genetic Associations of Type 2 Diabetes with Islet Amyloid Polypeptide Processing and Degrading Pathways in Asian Populations

Type 2 diabetes (T2D) is a complex disease characterized by beta cell dysfunctions. Islet amyloid polypeptide (IAPP) is highly conserved and co-secreted with insulin with over 40% of autopsy cases of T2D showing islet amyloid formation due to IAPP aggregation. Dysregulation in IAPP processing, stabi...

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Detalles Bibliográficos
Autores principales: Lam, Vincent Kwok Lim, Ma, Ronald Ching Wan, Lee, Heung Man, Hu, Cheng, Park, Kyong Soo, Furuta, Hiroto, Wang, Ying, Tam, Claudia Ha Ting, Sim, Xueling, Ng, Daniel Peng-Keat, Liu, Jianjun, Wong, Tien-Yin, Tai, E. Shyong, Morris, Andrew P., Tang, Nelson Leung Sang, Woo, Jean, Leung, Ping Chung, Kong, Alice Pik Shan, Ozaki, Risa, Jia, Wei Ping, Lee, Hong Kyu, Nanjo, Kishio, Xu, Gang, Ng, Maggie Chor Yin, So, Wing-Yee, Chan, Juliana Chung Ngor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679113/
https://www.ncbi.nlm.nih.gov/pubmed/23776430
http://dx.doi.org/10.1371/journal.pone.0062378

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