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Association between Adverse Childhood Experiences and Diagnosis of Cancer
OBJECTIVE: Adverse childhood experiences (ACEs) are linked to multiple adverse health outcomes. This study examined the association between ACEs and cancer diagnosis. METHODS: Data from the 2010 Behavioral Risk Factor Surveillance System (BRFSS) survey were used. The BRFSS is the largest ongoing tel...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679131/ https://www.ncbi.nlm.nih.gov/pubmed/23776494 http://dx.doi.org/10.1371/journal.pone.0065524 |
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author | Brown, Monique J. Thacker, Leroy R. Cohen, Steven A. |
author_facet | Brown, Monique J. Thacker, Leroy R. Cohen, Steven A. |
author_sort | Brown, Monique J. |
collection | PubMed |
description | OBJECTIVE: Adverse childhood experiences (ACEs) are linked to multiple adverse health outcomes. This study examined the association between ACEs and cancer diagnosis. METHODS: Data from the 2010 Behavioral Risk Factor Surveillance System (BRFSS) survey were used. The BRFSS is the largest ongoing telephone health survey, conducted in all US states, the District of Columbia, Puerto Rico, Guam and the U.S. Virgin Islands, and provides data on a variety of health issues among the non-institutionalized adult population. Principal component analysis (PCA) was used to derive components for ACEs. Multivariable logistic regression models were used to provide adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between ACE components and overall, childhood and adulthood cancer, adjusting for confounders such as age, gender, race/ethnicity, income, educational status, marital status, and insurance status. RESULTS: Approximately 62% of respondents reported being exposed to ACEs and about one in ten respondents reported ever having been diagnosed with cancer. Component 1, which had the sexual abuse variables with the highest weights, was significantly associated with adulthood cancer (adjusted OR: 1.21; 95% CI: 1.03–1.43). CONCLUSION: The association between ACEs and adulthood cancer may be attributable to disease progression through association of ACEs with risk factors for other chronic diseases. More research should focus on the impact of sexual abuse ACEs and adverse health outcomes. |
format | Online Article Text |
id | pubmed-3679131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36791312013-06-17 Association between Adverse Childhood Experiences and Diagnosis of Cancer Brown, Monique J. Thacker, Leroy R. Cohen, Steven A. PLoS One Research Article OBJECTIVE: Adverse childhood experiences (ACEs) are linked to multiple adverse health outcomes. This study examined the association between ACEs and cancer diagnosis. METHODS: Data from the 2010 Behavioral Risk Factor Surveillance System (BRFSS) survey were used. The BRFSS is the largest ongoing telephone health survey, conducted in all US states, the District of Columbia, Puerto Rico, Guam and the U.S. Virgin Islands, and provides data on a variety of health issues among the non-institutionalized adult population. Principal component analysis (PCA) was used to derive components for ACEs. Multivariable logistic regression models were used to provide adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between ACE components and overall, childhood and adulthood cancer, adjusting for confounders such as age, gender, race/ethnicity, income, educational status, marital status, and insurance status. RESULTS: Approximately 62% of respondents reported being exposed to ACEs and about one in ten respondents reported ever having been diagnosed with cancer. Component 1, which had the sexual abuse variables with the highest weights, was significantly associated with adulthood cancer (adjusted OR: 1.21; 95% CI: 1.03–1.43). CONCLUSION: The association between ACEs and adulthood cancer may be attributable to disease progression through association of ACEs with risk factors for other chronic diseases. More research should focus on the impact of sexual abuse ACEs and adverse health outcomes. Public Library of Science 2013-06-11 /pmc/articles/PMC3679131/ /pubmed/23776494 http://dx.doi.org/10.1371/journal.pone.0065524 Text en © 2013 Brown et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Brown, Monique J. Thacker, Leroy R. Cohen, Steven A. Association between Adverse Childhood Experiences and Diagnosis of Cancer |
title | Association between Adverse Childhood Experiences and Diagnosis of Cancer |
title_full | Association between Adverse Childhood Experiences and Diagnosis of Cancer |
title_fullStr | Association between Adverse Childhood Experiences and Diagnosis of Cancer |
title_full_unstemmed | Association between Adverse Childhood Experiences and Diagnosis of Cancer |
title_short | Association between Adverse Childhood Experiences and Diagnosis of Cancer |
title_sort | association between adverse childhood experiences and diagnosis of cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679131/ https://www.ncbi.nlm.nih.gov/pubmed/23776494 http://dx.doi.org/10.1371/journal.pone.0065524 |
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