Synthesis of Indole Derived Protease-Activated Receptor 4 Antagonists and Characterization in Human Platelets

Protease activated receptor-4 (PAR4) is one of the thrombin receptors on human platelets and is a potential target for the management of thrombotic disorders. We sought to develop potent, selective, and novel PAR4 antagonists to test the role of PAR4 in thrombosis and hemostasis. Development of an e...

Descripción completa

Detalles Bibliográficos
Autores principales: Young, Summer E., Duvernay, Matthew T., Schulte, Michael L., Lindsley, Craig W., Hamm, Heidi E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679140/
https://www.ncbi.nlm.nih.gov/pubmed/23776495
http://dx.doi.org/10.1371/journal.pone.0065528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679140/
https://www.ncbi.nlm.nih.gov/pubmed/23776495
http://dx.doi.org/10.1371/journal.pone.0065528

Ejemplares similares