Resistance Mutations outside the Integrase Coding Region Have an Effect on Human Immunodeficiency Virus Replicative Fitness but Do Not Affect Its Susceptibility to Integrase Strand Transfer Inhibitors

Most studies describing phenotypic resistance to integrase strand transfer inhibitors have analyzed viruses carrying only patient-derived HIV-1 integrase genes (INT-recombinant viruses). However, to date, many of the patients on INSTI-based treatment regimes, such as raltegravir (RAL), elvitegravir...

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Detalles Bibliográficos
Autores principales: Weber, Jan, Rose, Justine D., Vazquez, Ana C., Winner, Dane, Margot, Nicolas, McColl, Damian J., Miller, Michael D., Quiñones-Mateu, Miguel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679210/
https://www.ncbi.nlm.nih.gov/pubmed/23776513
http://dx.doi.org/10.1371/journal.pone.0065631

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