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Structural Definition Is Important for the Propagation of the Yeast [PSI(+)] Prion

Prions are propagated in Saccharomyces cerevisiae with remarkable efficiency, yet we know little about the structural basis of sequence variations in the prion protein that support or prohibit propagation of the prion conformation. We show that certain single-amino-acid substitutions in the prion pr...

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Detalles Bibliográficos
Autores principales:	Marchante, Ricardo, Rowe, Michelle, Zenthon, Jo, Howard, Mark J., Tuite, Mick F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679450/ https://www.ncbi.nlm.nih.gov/pubmed/23746351 http://dx.doi.org/10.1016/j.molcel.2013.05.010

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