Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a

Development of tolerance to endotoxin prevents sustained hyper inflammation during systemic infections. Here we report for the first time that chronic morphine treatment tempers endotoxin tolerance resulting in persistent inflammation, septicemia and septic shock. Morphine was found to down-regulate...

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Autores principales: Banerjee, Santanu, Meng, Jingjing, Das, Subhas, Krishnan, Anitha, Haworth, Justin, Charboneau, Richard, Zeng, Yan, Ramakrishnan, Sundaram, Roy, Sabita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679508/
https://www.ncbi.nlm.nih.gov/pubmed/23756365
http://dx.doi.org/10.1038/srep01977
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author Banerjee, Santanu
Meng, Jingjing
Das, Subhas
Krishnan, Anitha
Haworth, Justin
Charboneau, Richard
Zeng, Yan
Ramakrishnan, Sundaram
Roy, Sabita
author_facet Banerjee, Santanu
Meng, Jingjing
Das, Subhas
Krishnan, Anitha
Haworth, Justin
Charboneau, Richard
Zeng, Yan
Ramakrishnan, Sundaram
Roy, Sabita
author_sort Banerjee, Santanu
collection PubMed
description Development of tolerance to endotoxin prevents sustained hyper inflammation during systemic infections. Here we report for the first time that chronic morphine treatment tempers endotoxin tolerance resulting in persistent inflammation, septicemia and septic shock. Morphine was found to down-regulate endotoxin/LPS induced miR-146a and 155 in macrophages. However, only miR-146a over expression, but not miR-155 abrogates morphine mediated hyper-inflammation. Conversely, antagonizing miR-146a (but not miR-155) heightened the severity of morphine-mediated hyper-inflammation. These results suggest that miR-146a acts as a molecular switch controlling hyper-inflammation in clinical and/or recreational use of morphine.
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spelling pubmed-36795082013-06-12 Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a Banerjee, Santanu Meng, Jingjing Das, Subhas Krishnan, Anitha Haworth, Justin Charboneau, Richard Zeng, Yan Ramakrishnan, Sundaram Roy, Sabita Sci Rep Article Development of tolerance to endotoxin prevents sustained hyper inflammation during systemic infections. Here we report for the first time that chronic morphine treatment tempers endotoxin tolerance resulting in persistent inflammation, septicemia and septic shock. Morphine was found to down-regulate endotoxin/LPS induced miR-146a and 155 in macrophages. However, only miR-146a over expression, but not miR-155 abrogates morphine mediated hyper-inflammation. Conversely, antagonizing miR-146a (but not miR-155) heightened the severity of morphine-mediated hyper-inflammation. These results suggest that miR-146a acts as a molecular switch controlling hyper-inflammation in clinical and/or recreational use of morphine. Nature Publishing Group 2013-06-12 /pmc/articles/PMC3679508/ /pubmed/23756365 http://dx.doi.org/10.1038/srep01977 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Banerjee, Santanu
Meng, Jingjing
Das, Subhas
Krishnan, Anitha
Haworth, Justin
Charboneau, Richard
Zeng, Yan
Ramakrishnan, Sundaram
Roy, Sabita
Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a
title Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a
title_full Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a
title_fullStr Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a
title_full_unstemmed Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a
title_short Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a
title_sort morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of mir-146a
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679508/
https://www.ncbi.nlm.nih.gov/pubmed/23756365
http://dx.doi.org/10.1038/srep01977
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