Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a

Development of tolerance to endotoxin prevents sustained hyper inflammation during systemic infections. Here we report for the first time that chronic morphine treatment tempers endotoxin tolerance resulting in persistent inflammation, septicemia and septic shock. Morphine was found to down-regulate...

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Detalles Bibliográficos
Autores principales: Banerjee, Santanu, Meng, Jingjing, Das, Subhas, Krishnan, Anitha, Haworth, Justin, Charboneau, Richard, Zeng, Yan, Ramakrishnan, Sundaram, Roy, Sabita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679508/
https://www.ncbi.nlm.nih.gov/pubmed/23756365
http://dx.doi.org/10.1038/srep01977

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